ArticleBMC complementary medicine and therapies2020
GC-MS analysis of Myrtus communis extract and its antibacterial activity against Gram-positive bacteria.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Chemical Characterization, Evaluation of Antimicrobial Potential, and Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2026Article
- Antimicrobial evaluation ofFrontiers in microbiology · 2026Article
- Isolation, identification, and bioactivity evaluation of endophytic fungi from Ruta graveolens: insights into antimicrobial and antioxidant potential.Folia microbiologica · 2025Article
- Bacillus toyonensis BAR1, a yellow-pigment producing endophyte of Berberis aristata DC: a potential source of bioactive and antimicrobial compounds.Folia microbiologica · 2025Article
- Article
- Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells.Antioxidants (Basel, Switzerland) · 2025Article
- Article
- Antimycobacterial and Anticancer Properties ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Comparison of the Scolicidal Activity of Two Leaves Extracts of Myrtus communis from Algeria Against Echinococcus granulosus Sensu Lato Protoscoleces.Acta parasitologica · 2024Article
- From Environmental Toxicants to Antibacterial Agents: BPA Analogues Selectively Inhibit the Growth of Gram-Positive Bacteria by Disturbing Biosynthesis of the Cell Wall.Environment & health (Washington, D.C.) · 2023Article
- Mediterranean Plants with Antimicrobial Activity againstMicroorganisms · 2023Article
- Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme.Antibiotics (Basel, Switzerland) · 2023Article
- Myrtle: a versatile medicinal plant.Nutrire : revista de Sociedade Brasileira de Alimentacao e Nutricao = journal of the Brazilian Society of Food and Nutrition · 2023Review
- Plants with Antimicrobial Activity Growing in Italy: A Pathogen-Driven Systematic Review for Green Veterinary Pharmacology Applications.Antibiotics (Basel, Switzerland) · 2022Review
- Down-regulation of biofilm-associated genes in mecA-positive methicillin-resistant S. aureus treated with M. communis extract and its antibacterial activity.AMB Express · 2021Article
- In vitro cytotoxicity of Aspilia pluriseta Schweinf. extract fractions.BMC research notes · 2021Article
- Antimicrobial activity, phytochemical characterization and gas chromatography-mass spectrometry analysis ofHeliyon · 2020Article
- Secondary Metabolites ofBioMed research international · 2020Article
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4 authors.
Funding
Abstract
backgroundMyrtus communis is a typical plant of Mediterranean area. The different parts of this plant such as berries, branches, and leaves have been used worldwide as a traditional/folk medicine for the treatment of various ailments and diseases.
methodsEthanolic leaf extract of the plant was prepared by Soxhlet extraction method. Zone of inhibition, minimum inhibitory concentration and minimal bactericidal concentration were determined by well diffusion method and microplate alamar blue assay. GC-MS analysis was carried out to identify the compounds present in the extract. Microscopy and ImageJ software were used respectively for morphology and cell-length measurements. GraphPad Prism was used for statistical analysis.
resultsThe ethanolic extract showed strong inhibitory effect against Gram-positive and acid-fast bacteria with significant inhibition-zone size (9-25 mm), MIC (4.87-78 μg/ml), as well as MBC (0.3-20 mg/ml). However, no effect was observed on the growth of Gram-negative bacteria. The growth inhibition was found to be associated with the damage of cell wall as the extract-treated cells were sensitive to cell wall-targeting antibiotics and displayed the cell wall damage-depicting morphological defects. GC-MS analysis confirmed the presence of novel compounds in addition to the most representative compounds of the essential oils/extracts of M. communis of other country origins.
conclusionThese results demonstrate that M. communis leaf extract could be the source of compounds to be used for the treatment of Gram-positive bacterial infections. This is the first report, which provides insights into the mechanism of action of the extract in inhibiting the growth of Gram-positive bacteria.
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