ArticleBMC cardiovascular disorders2020
The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis.
Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The mediating role of fasting plasma glucose and systolic blood pressure in the association between Chinese visceral adiposity index and carotid atherosclerosis: a cross-sectional study.Scientific reports · 2026Article
- Predictors of Late Adverse Outcomes After Carotid Endarterectomy.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Glucose-lowering medications and glucose levels as the major determinants of progression of carotid atherosclerosis in middle-aged adults and elders: a community-based prospective study.Frontiers in endocrinology · 2024Article
- Sex-specific risk factors of carotid atherosclerosis progression in a high-risk population of cardiovascular disease.Clinical cardiology · 2023Article
- Obesity Prevalence and Associated Socio-Demographic Characteristics and Health Behaviors in Russia and Norway.International journal of environmental research and public health · 2022Article
- Association Between a Body Shape Index and Subclinical Carotid Atherosclerosis in Population Free of Cardiovascular and Cerebrovascular Diseases.Journal of atherosclerosis and thrombosis · 2022Article
- Exercise Training: The Holistic Approach in Cardiovascular Prevention.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Review
- Transition from metabolically healthy to unhealth status associated with risk of carotid artery plaque in Chinese adults.BMC cardiovascular disorders · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFew reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of plaque burden is mediated by cardiometabolic markers.
methodsFour thousand three hundred forty-five adults (median age 60) from the population-based Tromsø Study were followed over 7 years from the first carotid ultrasound screening to the next. The progression of carotid atherosclerosis was measured in three ways: incidence of plaques in previously plaque-free participants; change in the number of plaques; and total plaque area (TPA). We used generalised linear models to investigate the association between each adiposity measure - body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) - and each outcome. Models were adjusted for potential confounders (age, sex, smoking, education, physical activity). The pathways through which any associations observed might operate were investigated by further adjusting for cardiometabolic mediators (systolic blood pressure, cholesterol, and HbA1c).
resultsThere was little evidence that adiposity was related to the formation of new plaques during follow-up. However, abdominal adiposity was associated with TPA progression. WHtR showed the largest effect size (mean change in TPA per one standard deviation (SD) increase in WHtR of 0.665 mm
conclusionsAbdominal obesity indirectly measured with WC seems more strongly associated with the progression of TPA than general obesity. These associations appear to be largely mediated by known cardiometabolic markers.
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