ArticleBMC cardiovascular disorders2020
Research into the intervention effect of folic acid on arsenic-induced heart abnormalities in fetal rats during the periconception period.
Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Epigenetics: A link between toxicants and diseases.iScience · 2025Review
- Prenatal exposure to barium and arsenic and the odds of congenital heart defects in offspring: a nested case-control study within a birth cohort in Lanzhou, China.Frontiers in public health · 2025Article
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- D-Limonene Alleviates Oxidative Stress Injury of the Testis Induced by Arsenic in Rat.Biological trace element research · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- The dimethadione-exposed rat fetus: an animal model for the prenatal ultrasound characterization of ventricular septal defect.BMC cardiovascular disorders · 2023Article
- Prepregnancy exposure to dietary arsenic and congenital heart defects.Birth defects research · 2023Article
- Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review.Frontiers in nutrition · 2023Review
- Melatonin Prevents NaAsOAntioxidants (Basel, Switzerland) · 2022Article
- Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation.Frontiers in pharmacology · 2022Article
- Functional and structural phenotyping of cardiomyocytes in the 3D organization of embryoid bodies exposed to arsenic trioxide.Scientific reports · 2021Article
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I-Animal Model Studies.Toxics · 2021Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe incidence of CHD is the highest among birth defects and is increasing year to year. CHD seriously harms the health of infants and young children and presents a large economic burden to families and society. The pathogenesis of CHD and preventive measures are the focus of current research. Our research aimed to explore the intervention effect of folic acid on heart abnormalities resulting from sodium arsenic (NaAsO
methodsSixty 35-day-old female SD rats were randomly divided into 5 groups with 12 rats in each group. Group A was the control group. The rats were given distilled water and ordinary chow. The rats in group B were given distilled water containing 75 mg/L NaAsO
resultsThe embryo weight and placental weight of groups B-E were significantly lower than those of group A (P < 0.05). The heart malformation rate of the fetal rats in groups B-E was significantly higher than that of the fetal rats in group A (P < 0.05). We found that the level of H3K9 acetylation in fetal rat cardiomyocytes in groups B-E was significantly higher than that in group A (P < 0.05) and that the level of H3K9 acetylation in groups C-E was lower than that in group B (P < 0.05). The mRNA level of Mef2C in fetal rat cardiomyocytes in group B-E was significantly higher than that in group A (P < 0.05), and the mRNA level of Mef2C in groups C-E was significantly lower than that in group B (P < 0.05).
conclusionSupplementation with folic acid during the periconception period can interfere with the toxic effects of arsenic on the heart. The mechanism may be that lowering the acetylation levels of histone H3K9 in heart tissues leads to decreased expression levels of Mef2C, which may play a protective role in heart development in fetal rats.
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