Evidence map›Paper›PMID 32183576›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition.

Walaa M El-Husseiny, Magda A-A El-Sayed, Adel S El-Azab, Nawaf A AlSaif, Mohammed M Alanazi, Alaa A-M Abdel-Aziz

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Design, synthesis, antitumor evaluation, and molecular docking of novel pyrrolo[2,3-d]pyrimidine as multi-kinase inhibitors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Walaa M El-HusseinyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Magda A-A El-SayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0001-9599-9248
Adel S El-AzabDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0001-7197-1515
Nawaf A AlSaifDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohammed M AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alaa A-M Abdel-AzizDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0002-3362-9337
King Saud University · SADamietta University · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 24 compounds was synthesised based on a 2-cyclopentyloxyanisole scaffold

Indexed as

Molecular Docking SimulationAnisolesAntineoplastic AgentsCell Line, TumorCell ProliferationCyclic Nucleotide Phosphodiesterases, Type 4Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructurePhosphodiesterase 4 InhibitorsStructure-Activity RelationshipTumor Necrosis Factor-alphaanisoleAnisolesAntineoplastic AgentsCyclic Nucleotide Phosphodiesterases, Type 4Cyclooxygenase 2Cyclooxygenase 2 InhibitorsPDE4B protein, humanPhosphodiesterase 4 InhibitorsTumor Necrosis Factor-alpha2-cyclopentyloxyanisole scaffoldantitumor activityenzyme inhibition assay; docking studySynthesis

Identifiers

PMID32183576
PMCPMC7144195
OpenAlexW3011690831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.