Evidence map›Paper›PMID 32183548›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways.

Runwei Jiao, Fanxing Xu, Xiaofang Huang, Haonan Li, Weiwei Liu, Hao Cao, Linghe Zang, Zhanlin Li, Huiming Hua, Dahong Li

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Runwei JiaoKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Fanxing XuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Xiaofang HuangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Haonan LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Weiwei LiuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Hao CaoSchool of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Linghe ZangSchool of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Zhanlin LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Huiming HuaKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Dahong LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs. Among them, compound

Indexed as

Antineoplastic AgentsCell CycleCell DeathCell ProliferationChromonesDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansK562 CellsMembrane Potential, MitochondrialMolecular Docking SimulationMolecular StructureNitric OxideStructure-Activity RelationshipAntineoplastic AgentsChromonesNitric OxideantiproliferativeapoptosisChromonenitric oxideselectivity

Identifiers

PMID32183548
PMCPMC7144234
OpenAlexW3012243856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.