Evidence map›Paper›PMID 32183450›Full record

ArticleInternational journal of molecular sciences2020

Exploring miR-9 Involvement in

Silvia Mercurio, Silvia Cauteruccio, Raoul Manenti, Simona Candiani, Giorgio Scarì, Emanuela Licandro, Roberta Pennati

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Silvia MercurioDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0002-2587-8237
Silvia CauteruccioDepartment of Chemistry, Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0002-9540-9073
Raoul ManentiDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0001-6071-8194
Simona CandianiDepartment of Earth Science, Environment and Life, Università degli Studi di Genova, 16132 Genova, Italy.ORCID 0000-0002-4453-5475
Giorgio ScarìDepartment of Biosciences, Università degli Studi di Milano, 20133 Milano, Italy.
Emanuela LicandroDepartment of Chemistry, Università degli Studi di Milano, 20133 Milano, Italy.
Roberta PennatiDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy.
University of Milan · ITUniversity of Genoa · IT

Funding

Fondazione Cariplo 2013-0752
6 · The paper itself

Abstract

The microRNAs are small RNAs that regulate gene expression at the post-transcriptional level and can be involved in the onset of neurodegenerative diseases and cancer. They are emerging as possible targets for antisense-based therapy, even though the in vivo stability of miRNA analogues is still questioned. We tested the ability of peptide nucleic acids, a novel class of nucleic acid mimics, to downregulate miR-9 in vivo in an invertebrate model organism, the ascidian

Indexed as

Cell DifferentiationCiona intestinalisMicroRNAsNeurogenesisPeptide Nucleic AcidsAnimalsLarvaNeuronsMicroRNAsPeptide Nucleic Acidsantisense therapyinvertebratemicroRNAnervous system developmentPNAtunicates

Identifiers

PMID32183450
PMCPMC7139483
OpenAlexW3012345028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.