Evidence map›Paper›PMID 32183400›Full record

ArticleCells2020

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis.

Ainhoa Lapitz, Ander Arbelaiz, Colm J O'Rourke, Jose L Lavin, Adelaida La Casta, Cesar Ibarra, Juan P Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
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  4. Cholangiocarcinoma 2026: status quo, unmet needs and priorities.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Cholangiocarcinoma: The era of liquid biopsy.World journal of gastroenterology · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Isolating Astrocyte-Derived Extracellular Vesicles From Urine.International journal of nanomedicine · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Ainhoa LapitzDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Ander ArbelaizDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Colm J O'RourkeBiotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, 2200, Copenhagen, Denmark.
Jose L LavinCIC bioGUNE, Genome Analysis Platform, 48160, Derio, Spain.
Adelaida La CastaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Cesar IbarraHospital of Cruces, 48903, Bilbao, Spain.
Juan P Jimeno"Complejo Hospitalario de Navarra", 31008, Pamplona, Spain.
Alvaro Santos-LasoDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Laura Izquierdo-SanchezDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Centre, Saarland University, 66421, Homburg, Germany.
Maria J PerugorriaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Raul Jimenez-AgueroDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Alberto Sanchez-CamposHospital of Cruces, 48903, Bilbao, Spain.
Ioana RiañoDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Esperanza GónzalezCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Exosomes Laboratory, 48160, Derio, Spain.
Frank LammertDepartment of Medicine II, Saarland University Medical Centre, Saarland University, 66421, Homburg, Germany.
Marco Marzioni"Università Politecnica delle Marche", Department of Gastroenterology, 60121, Ancona, Italy.
Rocio I R MaciasCarlos III National Institute of Health, Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), 28220, Madrid, Spain.
Jose J G MarinCarlos III National Institute of Health, Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), 28220, Madrid, Spain.
Tom H KarlsenNorwegian PSC Research Center, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, 0372, Oslo, Spain.
Luis BujandaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Juan M Falcón-PérezCarlos III National Institute of Health, Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), 28220, Madrid, Spain.
Jesper B AndersenBiotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, 2200, Copenhagen, Denmark.
Ana M AransayCIC bioGUNE, Genome Analysis Platform, 48160, Derio, Spain.
Pedro M RodriguesDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
Jesus M BanalesDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014, San Sebastian, Spain.
University of the Basque Country · ESInstituto de Salud Carlos III · ESCIC bioGUNE · ESHospital de Cruces · ESIkerbasque · ESSaarland University · DEComplejo Hospitalario de Navarra · ESMarche Polytechnic University · IT

Funding

PROBIOTICS IN NEONATAL GUT MICROBIAL ECOLOGYR03TW000601 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI PANIGRAHI, PINAKI · 1996 to 1998
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6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersCholangiocarcinomaExtracellular VesiclesFemaleHumansLiquid BiopsyMaleRNABiomarkersRNAbiomarkerscholangiocarcinomaextracellular vesiclesliquid biopsytranscriptomics

Identifiers

PMID32183400
PMCPMC7140677
OpenAlexW3010770699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.