ArticleMetabolites2020
Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes.
Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Biomarkers of hypoxic-ischemic encephalopathy: a systematic review.World journal of pediatrics : WJP · 2023Pooled it
- Magnesium Sulfate in Neonatal Hypoxic-Ischemic Encephalopathy: Bridging the Gap Between Molecular Neuroprotection and Clinical Outcomes.Current issues in molecular biology · 2026Review
- Genetic Research on Neuropsychiatric Disorders and Complex Human Diseases.Biomedicines · 2026Article
- Hypoxanthine-early biomarker of outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy.Pediatric research · 2026Article
- Urinary metabolome at birth in patients with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and long-term neurodevelopmental outcomes: a 7-year follow up.Journal of translational medicine · 2025Article
- Cerebral Oxygenation Pattern during Therapeutic Hypothermia after Perinatal Asphyxia: A Single Center Cohort Study.Neonatology · 2025Article
- Detection of Sub-acute Brain Injury and Hypoxic-ischemic Encephalopathy using I2C2-WGO and CO-GW-RNN.Current medical imaging · 2025Article
- Brain metabolism after therapeutic hypothermia for murine hypoxia-ischemia using hyperpolarized [1-NMR in biomedicine · 2024Article
- Searching molecular biomarkers correlating with BSID-III at 24 months in infants with neonatal hypoxic-ischemic encephalopathy.European journal of pediatrics · 2024Article
- Identification of Metabolomic Signatures for Ischemic Hypoxic Encephalopathy Using a Neonatal Rat Model.Children (Basel, Switzerland) · 2023Article
- A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy.Translational pediatrics · 2023Review
- A Cohort Study of Gastric Fluid and Urine Metabolomics for the Prediction of Survival in Severe Prematurity.Metabolites · 2023Article
- Noninvasive monitoring of evolving urinary metabolic patterns in neonatal encephalopathy.Pediatric research · 2022Article
- Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach.Antioxidants (Basel, Switzerland) · 2021Review
- A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Article
- Phenylacetylglutamine, a Novel Biomarker in Acute Ischemic Stroke.Frontiers in cardiovascular medicine · 2021Article
- A Metabolomic Approach in Search of Neurobiomarkers of Perinatal Asphyxia: A Review of the Current Literature.Frontiers in pediatrics · 2021Review
- Precision Medicine in Neonates: A Tailored Approach to Neonatal Brain Injury.Frontiers in pediatrics · 2021Review
- Metabolomics Applications in Children: A Right Way to Go.Metabolites · 2020Article
- Artificial intelligence in maternal and child health: Current applications, translational gaps, and future research priorities.Women's health (London, England)Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of a cohort of 55 asphyxiated infants who evolved to moderate/severe HIE were collected between birth and completion of therapeutic hypothermia (TH). Samples were analyzed employing a quantitative gas chromatography-mass spectrometry method for the determination of lactate and pyruvate and an untargeted liquid chromatography-time-of-flight mass spectrometry method for metabolic fingerprinting. Brain injury was assessed employing magnetic resonance imaging (MRI). A critical assessment of the usefulness of lactate, pyruvate, and pyruvate/lactate for outcome prediction was carried out. Besides, metabolic fingerprinting identified a dynamic perturbation of eleven metabolic pathways, including amino acid and purine metabolism, and the steroid hormone biosynthesis, in newborns with pathologic MRI outcomes. Although data suggest the usefulness of lactate and pyruvate monitoring during 72 h for discerning outcomes, only the steroid hormone biosynthesis pathway was significantly altered in early plasma samples (i.e., before the initiation of TH). This study highlights pathways that might potentially be targeted for biomarker discovery or adjuvant therapies to be combined with TH.
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