Evidence map›Paper›PMID 32183361›Full record

ArticleGenes2020

Corinne Gurtner, Petra Hug, Miriam Kleiter, Kernt Köhler, Elisabeth Dietschi, Vidhya Jagannathan, Tosso Leeb

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Corinne GurtnerInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Petra HugInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Miriam KleiterDepartment/Hospital for Companion Animals and Horses, University Clinic for Small Animals, Internal Medicine Small Animals, University of Veterinary Medicine, 1210 Vienna, Austria.
Kernt KöhlerInstitute of Veterinary Pathology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.
Elisabeth DietschiInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
University of Bern · CHJustus-Liebig-Universität Gießen · DEUniversity of Veterinary Medicine Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dog puppy loss by the age of six to eight weeks after normal development is relatively uncommon. Necropsy findings in two spontaneously deceased Belgian Shepherd puppies indicated an abnormal accumulation of material in several organs. A third deceased puppy exhibited mild signs of an inflammation in the central nervous system and an enteritis. The puppies were closely related, raising the suspicion of a genetic cause. Pedigree analysis suggested a monogenic autosomal recessive inheritance. Combined linkage and homozygosity mapping assigned the most likely position of a potential genetic defect to 13 genome segments totaling 82 Mb. The genome of an affected puppy was sequenced and compared to 645 control genomes. Three private protein changing variants were found in the linked and homozygous regions. Targeted genotyping in 96 Belgian Shepherd dogs excluded two of these variants. The remaining variant,

Indexed as

Anemia, SideroblasticAnimalsCardiomyopathiesCentral Nervous SystemDog DiseasesDogsGenes, RecessiveGenetic LinkageGenomeMutation, MissensePedigreeTyrosine-tRNA LigaseTyrosine-tRNA Ligaseanimal modelCanis lupus familiarisGroenendaelLaekenoisMalinoismitochondriumprecision medicineTervuerentranslationwhole genome sequence

Identifiers

PMID32183361
PMCPMC7140874
OpenAlexW3011017879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.