ReviewMolecules (Basel, Switzerland)2020
A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Urinary phytoestrogen levels and reduced thyroid hormone sensitivity: a cross-sectional analysis of NHANES 2007-2010.European journal of medical research · 2025Article
- Trace elements: Clinical perspectives in the critically ill.Journal of the Intensive Care Society · 2025Review
- Thyroid Hormone Deiodination-Mechanisms and Small Molecule Enzyme Mimics.Biomolecules · 2025Review
- Effects and Impact of Selenium on Human Health, A Review.Molecules (Basel, Switzerland) · 2024Review
- A study on the methylation patterns ofHeliyon · 2024Article
- Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals.Environment & health (Washington, D.C.) · 2024Review
- Article
- Effects of selenium and iodine on Kashin-Beck disease: an updated review.Frontiers in nutrition · 2024Review
- Selenium-More than Just a Fortuitous Sulfur Substitute in Redox Biology.Molecules (Basel, Switzerland) · 2023Review
- Halogen Bonding Involving Isomeric Isocyanide/Nitrile Groups.International journal of molecular sciences · 2023Article
- Halogen bonds, chalcogen bonds, pnictogen bonds, tetrel bonds and other σ-hole interactions: a snapshot of current progress.Acta crystallographica. Section C, Structural chemistry · 2023Article
- Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species.Environmental toxicology and chemistry · 2023Article
- Functionalized Selenium Nanoparticles Synergizes With Metformin to Treat Breast Cancer Cells Through Regulation of Selenoproteins.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Iodothyronine deiodinases (Dios) are involved in the regioselective removal of iodine from thyroid hormones (THs). Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site has been proposed to contribute to the mechanism for iodine removal. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known disruptors of various pathways of the endocrine system. Experimental evidence shows PBDEs and their hydroxylated metabolites (OH-BDEs) can inhibit Dio, while data regarding PCB inhibition are limited. These xenobiotics could inhibit Dio activity by competitively binding to the active site Sec through XB to prevent deiodination. XB interactions calculated using density functional theory (DFT) of THs, PBDEs, and PCBs to a methyl selenolate (MeSe
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