ArticleJournal of clinical medicine2020
Age- and Sex-Specific TSH Upper-Limit Reference Intervals in the General French Population: There Is a Need to Adjust Our Actual Practices.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association between thyroid function and Alzheimer's disease: A systematic review.Metabolic brain disease · 2021Pooled it
- Factors influencing the reference interval of thyroid-stimulating hormone in healthy adults: A systematic review and meta-analysis.Clinical endocrinology · 2021Pooled it
- Reference Intervals for Serum Thyroid-Stimulating Hormone Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Article
- Revisiting the TSH range in older adults: associations between subclinical hypothyroidism and geriatric conditions.Journal of the Endocrine Society · 2026Article
- Establishment of Reference Intervals for Plasma TSH Across the Lifespan in an Algerian Mediterranean Population.Journal of clinical laboratory analysis · 2026Article
- Thyroid hormones and energy metabolism in amyotrophic lateral sclerosis.Brain communications · 2026Article
- Comparison of thyroid hormones reference intervals based on thyroid antibody levels: A multicenter study.PloS one · 2026Article
- Article
- Reference intervals for thyroid-stimulating hormone in the adult Lebanese population: Results from the last decade.Heliyon · 2025Article
- EndoCompass Project: Research Roadmap for Thyroid Endocrinology.Hormone research in paediatrics · 2025Review
- The BioRef Infrastructure, a Framework for Real-Time, Federated, Privacy-Preserving, and Personalized Reference Intervals: Design, Development, and Application.Journal of medical Internet research · 2023Article
- The Impact of Age- and Sex-Specific Reference Ranges for Serum Thyrotropin and Free Thyroxine on the Diagnosis of Subclinical Thyroid Dysfunction: A Multicenter Study from Japan.Thyroid : official journal of the American Thyroid Association · 2023Article
- [A multi-center analysis of thyroid-stimulating hormone level in apparently healthy elderly population in China].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- The different outcomes in the elderly with subclinical hypothyroidism diagnosed by age-specific and non-age-specific TSH reference intervals: a prospectively observational study protocol.Frontiers in endocrinology · 2023Article
- Age-based factors modulating the required thyroxine dose to achieve thyrotropin suppression in intermediate-and high-risk papillary thyroid cancer.Frontiers in endocrinology · 2023Article
- Age-specific serum thyrotropin reference range for the diagnosis of subclinical hypothyroidism and its association with lipid profiles in the elderly population.Scientific reports · 2022Article
- Thyroid Function across the Lifespan: Do Age-Related Changes Matter?Endocrinology and metabolism (Seoul, Korea) · 2022Article
- The pattern of TSH and fT4 levels across different BMI ranges in a large cohort of euthyroid patients with obesity.Frontiers in endocrinology · 2022Article
- Sex Bias in Differentiated Thyroid Cancer.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that thyroid dysfunction increases with age. This study is aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration during adult life using routinely collected serum thyrotropin (TSH) data in a tertiary center from 2007 to 2018. Over 11 years, 295,775 TSH levels were measured in a single lab. Among the 156,025 TSH results available for analysis, 90,538 values were from female subjects, 82,019 were from patients aged >60 years and 26,825 were from patients aged >80 years. By using an indirect approach, we determined reference values of TSH adapted to age and sex, and we then evaluated the proportion of patients who would have been reclassified with these reference values. The median TSH ranged from 1.2-1.4 mUI/L during the study period. The upper limit of reference range of TSH increased with age; in females the median to 97.5th percentile values increased continuously from the age of 30 years to the oldest age group. Using new calculated reference values in patients with TSH above the conventional upper-limit reference value (4 mUI/L), the proportion of results reclassified as within the reference interval among patients aged >60 years ranged, according to age group, from 50.5% to 65.1% of females and from 33.0% to 37.7% of males. The use of TSH age-specific and sex-specific upper-limit reference values led to the reclassification of a great number of samples, notably among women. This suggests that age-specific TSH upper-limit reference intervals in daily practice should be used in order to avoid misclassification.
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Registered trials
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