Evidence map›Paper›PMID 32183173›Full record

ArticleInternational journal of molecular sciences2020

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the

Iswariyaraja Sridevi Gurubaran, Johanna Viiri, Ali Koskela, Juha M T Hyttinen, Jussi J Paterno, Gréta Kis, Miklós Antal, Arto Urtti, Anu Kauppinen, Szabolcs Felszeghy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Autophagy in ocular diseases: from mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Autophagy: a double-edged sword in ischemia-reperfusion injury.Cellular & molecular biology letters · 2025
    Review
  11. Article
  12. Multifocal vitelliform lesions associated with mitochondrial retinopathy.American journal of ophthalmology case reports · 2024
    Article
  13. Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  14. Review
  15. Review
  16. Review
  17. The mitophagy pathway and its implications in human diseases.Signal transduction and targeted therapy · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Iswariyaraja Sridevi GurubaranDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
Johanna ViiriDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
Ali KoskelaDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
Juha M T HyttinenDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
Jussi J PaternoDepartment of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-5442-4314
Gréta KisFaculty of Medicine, Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.
Miklós AntalFaculty of Medicine, Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.ORCID 0000-0002-2457-7387
Arto UrttiFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland.
Anu KauppinenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0001-8254-0200
Szabolcs FelszeghyInstitute of Dentistry and Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland.
Kai KaarnirantaDepartment of Ophthalmology and Kuopio University Hospital, University of Eastern Finland, 70029 Kuopio, Finland.
University of Eastern Finland · FIUniversity of Debrecen · HU

Funding

Academy of Finland 296840H2020 Marie Skłodowska-Curie Actions 722717The Kuopio University Hospital VTR grant 5503743
6 · The paper itself

Abstract

Increased oxidative stress and mitochondrial damage are observed in protein aggregation diseases, such as age-related macular degeneration (AMD). We have recently reported elevated levels of oxidative stress markers, damaged mitochondria, accumulating lysosomal lipofuscin and extracellular drusen-like structures in the retinal pigment epithelial cells (RPE) of the dry AMD-resembling

Indexed as

MitophagyAnimalsGene DeletionLysosomal-Associated Membrane Protein 2LysosomesMacular DegenerationMaleMiceMicrotubule-Associated ProteinsMitochondriaNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesPTEN-Induced Putative KinaseRetinal Pigment EpitheliumUbiquitin-Protein LigasesLysosomal-Associated Membrane Protein 2Map1lc3b protein, mouseMicrotubule-Associated ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2parkin proteinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein Ligasesageingage-related macular diseaseautolysosomal fusionmitochondrial damagemitophagyoxidative stressprotein aggregates

Identifiers

PMID32183173
PMCPMC7139489
OpenAlexW3012551305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.