Evidence map›Paper›PMID 32182904›Full record

ReviewJournal of clinical medicine2020

Central and Peripheral Neuromuscular Adaptations to Ageing.

Riccardo Borzuola, Arrigo Giombini, Guglielmo Torre, Stefano Campi, Erika Albo, Marco Bravi, Paolo Borrione, Chiara Fossati, Andrea Macaluso

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 6 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Riccardo BorzuolaDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Arrigo GiombiniDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Guglielmo TorreDepartment of Orthopaedic And Trauma Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Stefano CampiDepartment of Orthopaedic And Trauma Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Erika AlboDepartment of Orthopaedic And Trauma Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Marco BraviDepartment of Physical Medicine and Rehabilitation, Campus Bio-Medico University of Rome, 00128 Rome, Italy.ORCID 0000-0002-3396-4100
Paolo BorrioneDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.ORCID 0000-0003-0506-169X
Chiara FossatiDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Andrea MacalusoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Foro Italico University of Rome · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is accompanied by a severe muscle function decline presumably caused by structural and functional adaptations at the central and peripheral level. Although researchers have reported an extensive analysis of the alterations involving muscle intrinsic properties, only a limited number of studies have recognised the importance of the central nervous system, and its reorganisation, on neuromuscular decline. Neural changes, such as degeneration of the human cortex and function of spinal circuitry, as well as the remodelling of the neuromuscular junction and motor units, appear to play a fundamental role in muscle quality decay and culminate with considerable impairments in voluntary activation and motor performance. Modern diagnostic techniques have provided indisputable evidence of a structural and morphological rearrangement of the central nervous system during ageing. Nevertheless, there is no clear insight on how such structural reorganisation contributes to the age-related functional decline and whether it is a result of a neural malfunction or serves as a compensatory mechanism to preserve motor control and performance in the elderly population. Combining leading-edge techniques such as high-density surface electromyography (EMG) and improved diagnostic procedures such as functional magnetic resonance imaging (fMRI) or high-resolution electroencephalography (EEG) could be essential to address the unresolved controversies and achieve an extensive understanding of the relationship between neural adaptations and muscle decline.

Indexed as

agingcerebral cortexdynapeniaelderlymotor unitmuscle strengthneuralneuroplasticitysarcopenia

Identifiers

PMID32182904
PMCPMC7141192
OpenAlexW3010176210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.