Evidence map›Paper›PMID 32182891›Full record

ArticleInternational journal of environmental research and public health2020

Rationale, Study Design, and Cohort Characteristics for the Markers for Environmental Exposures (MEE) Study.

Rachel McFarland Lucia, Wei-Lin Huang, Andrea Alvarez, Daphne Thampy, Melodie Elyasian, Amanda Hidajat, Kailynn Yang, Danielle Forman, Asana Pebdani, Irene Masunaka and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Design, Spectral Insights, and Enhanced Antioxidant Potential of Novel Phenothiazine DerivativesAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Rachel McFarland LuciaDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Wei-Lin HuangDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Andrea AlvarezDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Daphne ThampyDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Melodie ElyasianDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Amanda HidajatDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Kailynn YangDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Danielle FormanDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Asana PebdaniDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Irene MasunakaDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Susie BrainPatient and Research Advocate, Markers for Environmental Exposures Study, Irvine, CA 92697, USA.
Diane HeditsianPatient and Research Advocate, Markers for Environmental Exposures Study, Irvine, CA 92697, USA.
Vivian LeePatient and Research Advocate, Markers for Environmental Exposures Study, Irvine, CA 92697, USA.
Deborah GoodmanDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Trina M Norden-KrichmarDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-0199-9915
Andrew O OdegaardDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.
Argyrios ZiogasDepartment of Medicine, University of California, Irvine, CA 92697, USA.
Hannah Lui ParkDepartment of Epidemiology, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-9973-1396
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental factors have been linked to many diseases and health conditions, but reliable assessment of environmental exposures is challenging. Developing biomarkers of environmental exposures, rather than relying on self-report, will improve our ability to assess the association of such exposures with disease. Epigenetic markers, most notably DNA methylation, have been identified for some environmental exposures, but identification of markers for additional exposures is still needed. The rationale behind the Markers for Environmental Exposures (MEE) Study was to (1) identify biomarkers, especially epigenetic markers, of environmental exposures, such as pesticides, air/food/water contaminants, and industrial chemicals that are commonly encountered in the general population; and (2) support the study of potential relationships between environmental exposures and health and health-related factors. The MEE Study is a cross-sectional study with potential for record linkage and follow-up. The well-characterized cohort of 400 postmenopausal women has generated a repository of biospecimens, including blood, urine, and saliva samples. Paired data include an environmental exposures questionnaire, a breast health questionnaire, dietary recalls, and a food frequency questionnaire. This work describes the rationale, study design, and cohort characteristics of the MEE Study. In addition to our primary research goals, we hope that the data and biorepository generated by this study will serve as a resource for future studies and collaboration.

Indexed as

Environmental ExposureBiomarkersCohort StudiesCross-Sectional StudiesFemaleHumansPesticidesBiomarkersPesticidesbiomarkerbiorepositoryDNA methylationenvironmental exposuresepigenetics

Identifiers

PMID32182891
PMCPMC7084413
OpenAlexW3010471455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.