Trial reportToxins2020
Botulinum Toxin Therapy for Managing Sleep Bruxism: A Randomized and Placebo-Controlled Trial.
Trial report in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pooled it
- Effectiveness of Botulinum Toxin Injection on Bruxism: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Aesthetic plastic surgery · 2023Pooled it
- Effectiveness of Biofeedback in Individuals with Awake Bruxism Compared to Other Types of Treatment: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Comparing botulinum toxin and biofeedback therapies for awake bruxism: a randomized clinical trial.BMC oral health · 2025Trial
- Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- One Molecule, Different Circuits? What Botulinum Toxin Can and Cannot Reveal About Craniocervical Comorbidity.Toxins · 2026Review
- Review
- The Effects of Botulinum Toxin on Sleep Bruxism: An Electromyographic Study with the Portable Bruxoff Holter System.Journal of clinical medicine · 2026Article
- Sleep Bruxism: A Narrative Review of Current Concepts, Mechanisms, and Clinical Implications.Journal of the Royal Society of New Zealand · 2026Review
- Association of sleep bruxism with obstructive sleep apnea and gastroesophageal reflux disease: a cross-sectional study in Egyptian governmental dental clinics.BMC oral health · 2026Article
- [Research trends on botulinum toxin A in bruxism: a bibliometric analysis].Revista medica del Instituto Mexicano del Seguro Social · 2025Review
- Facial volume reduction and masticatory function after masseter botulinum toxin injection: a prospective study.BMC oral health · 2025Article
- BoNT Injection into Temporomandibular Joint Alleviates TMJ Pain in Forced Mouth Opening Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Factors Influencing the Effectiveness of Botulinum Toxin Therapy in Bruxism Management.Toxins · 2025Article
- Spin Bias in randomized controlled trials of botulinum toxin for bruxism management: a meta-epidemiologic study.BMC medical research methodology · 2025Article
- Understanding the clinical management of co-occurring sleep-related bruxism and obstructive sleep apnea in adults: A narrative and critical review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Review
- Review
- Exploring New and Potential Indications for Botulinum Toxin Treatment: An Updated Literature Review.Cureus · 2024Review
- Review
- Clinical effect of botulinum toxin type A combined with autologous fat grafting in patients with nasolabial fold depression.World journal of clinical cases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The purpose of this study is to evaluate the effects of botulinum toxin type A (BoNT-A) for managing sleep bruxism (SB) in a randomized, placebo-controlled trial. Thirty SB subjects were randomly assigned into two groups evenly. The placebo group received saline injections into each masseter muscle, and the treatment group received BoNT-A injections into each masseter muscle. Audio-video-polysomnographic recordings in the sleep laboratory were made before, at four weeks after, and at 12 weeks after injection. Sleep and SB parameters were scored according to the diagnostic and coding manual of American Academy of Sleep Medicine. The change of sleep and SB parameters were investigated using repeated measures analysis of variance (RM-ANOVA). Twenty-three subjects completed the study (placebo group 10, treatment group 13). None of the SB episode variables showed a significant time and group interaction (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.