Evidence map›Paper›PMID 32182774›Full record

ArticleInternational journal of molecular sciences2020

The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.

Attilio Cannata, Chiara De Luca, Liudmila G Korkina, Nadia Ferlazzo, Riccardo Ientile, Monica Currò, Giulia Andolina, Daniela Caccamo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021
    Pooled it
  2. Placental SNV rs8192446 in theFrontiers in physiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Attilio CannataDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Chiara De LucaR & D Regulatory Affairs Department, Medena AG, Affoltern-am-Albis (ZH) CH-8910, Switzerland.
Liudmila G KorkinaCentre of Innovative Biotechnological Investigations Nanolab (CIBI-NANOLAB), Moscow 119571, Russia.
Nadia FerlazzoDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Riccardo IentileDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Monica CurròDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.ORCID 0000-0001-8852-7023
Giulia AndolinaDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Daniela CaccamoDepartment of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.ORCID 0000-0001-8593-9495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic inflammation and immune activation are striking features of multiple chemical sensitivity (MCS). The rs2298383 SNP of

Indexed as

AdultCase-Control StudiesCytokinesFemaleGenetic Predisposition to DiseaseGenotypeHumansInterferon-gammaInterleukin-4Leukocytes, MononuclearMaleMiddle AgedMultiple Chemical SensitivityPolymorphism, Single NucleotideReceptor, Adenosine A2ARNA, MessengerADORA2A protein, humanCytokinesInterferon-gammaInterleukin-4Receptor, Adenosine A2ARNA, MessengerADORA2A gene expressionADORA2A SNPgenetic background roleinflammatory cytokinesmultiple chemical sensitivityPBMC

Identifiers

PMID32182774
PMCPMC7084623
OpenAlexW3010002099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.