Evidence map›Paper›PMID 32182691›Full record

ArticleInternational journal of molecular sciences2020

Drinking and Water Handling in the Medaka Intestine: A Possible Role of Claudin-15 in Paracellular Absorption?

Christian K Tipsmark, Andreas M Nielsen, Maryline C Bossus, Laura V Ellis, Christina Baun, Thomas L Andersen, Jes Dreier, Jonathan R Brewer, Steffen S Madsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Christian K TipsmarkDepartment of Biological Sciences, University of Arkansas, SCEN 601, Fayetteville, AR 72701, USA.ORCID 0000-0003-1849-1998
Andreas M NielsenDepartment of Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Maryline C BossusDepartment of Biological Sciences, University of Arkansas, SCEN 601, Fayetteville, AR 72701, USA.ORCID 0000-0003-1292-9004
Laura V EllisDepartment of Biological Sciences, University of Arkansas, SCEN 601, Fayetteville, AR 72701, USA.
Christina BaunDepartment of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Thomas L AndersenDepartment of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.ORCID 0000-0002-2860-6317
Jes DreierDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Jonathan R BrewerDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
Steffen S MadsenDepartment of Biological Sciences, University of Arkansas, SCEN 601, Fayetteville, AR 72701, USA.ORCID 0000-0002-5785-7094
University of Southern Denmark · DKOdense University Hospital · DKUniversity of Arkansas at Fayetteville · USLyon College · US

Funding

Arkansas Biosciences Institute NANational Science Foundation IOS 1251616Natur og Univers, Det Frie Forskningsråd DFF-4181-00020
6 · The paper itself

Abstract

When euryhaline fish move between fresh water (FW) and seawater (SW), the intestine undergoes functional changes to handle imbibed SW. In Japanese medaka, the potential transcellular aquaporin-mediated conduits for water are paradoxically downregulated during SW acclimation, suggesting paracellular transport to be of principal importance in hyperosmotic conditions. In mammals, intestinal claudin-15 (CLDN15) forms paracellular channels for small cations and water, which may participate in water transport. Since two

Indexed as

AnimalsClaudinsEnterocytesFemaleFish ProteinsIntestinal MucosaMaleOccludinOryziasSalinityTight JunctionsWaterclaudin 15ClaudinsFish ProteinsOccludinWateraquaporinclaudindrinking rateenterocyteepithelial fluid transportoccludinosmoregulationparacellular

Identifiers

PMID32182691
PMCPMC7085193
OpenAlexW3009399460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.