Evidence map›Paper›PMID 32182577›Full record

ArticleNeuroImage. Clinical2020

Youth with elevated psychopathic traits exhibit structural integrity deficits in the uncinate fasciculus.

J Michael Maurer, Subhadip Paul, Nathaniel E Anderson, Prashanth K Nyalakanti, Kent A Kiehl

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J Michael MaurerDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA; The Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, USA. Electronic address: maurerjmichael@gmail.com.
Subhadip PaulThe Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, USA.
Nathaniel E AndersonThe Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, USA.
Prashanth K NyalakantiThe Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, USA.
Kent A KiehlDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA; The Mind Research Network (MRN) & Lovelace Biomedical and Environmental Research Institute (LBERI), Albuquerque, NM, USA. Electronic address: kkiehl@mrn.org.

Funding

Externalizing outcomes in high risk youthR01HD092331 · NICHD · THE MIND RESEARCH NETWORK · PI KIEHL, KENT A · 2017 to 2022
$3.5M
Brain changes and outcomes accompanying evidence-based treatment in high-risk youthR01HD082257 · NICHD · THE MIND RESEARCH NETWORK · PI CALDWELL, MICHAEL F., KIEHL, KENT A · 2015 to 2020
$3.5M
NEUROCOGNITIVE ASSESSMENT OF 'CALLOUS' CONDUCT DISORDERED YOUTHR01MH071896 · NIMH · THE MIND RESEARCH NETWORK · PI KIEHL, KENT A · 2006 to 2010
$1.7M
NICHD NIH HHS R01 HD082257NICHD NIH HHS R01 HD092331NIMH NIH HHS R01 MH071896
6 · The paper itself

Abstract

Youth with elevated psychopathic traits represent a particularly severe subgroup of adolescents characterized by extreme behavioral problems and exhibit comparable neurocognitive deficits as adult offenders with psychopathic traits. A consistent finding among adults with elevated psychopathic traits is reduced white matter structural integrity of the right uncinate fasciculus (UF). The UF is a major white matter tract that connects regions of the anterior temporal lobe (i.e., the amygdala) to higher-order executive control regions, including the ventromedial prefrontal cortex. However, the relationship between youth psychopathic traits and structural integrity of the UF has been mixed, with some studies identifying a negative relationship between adolescent psychopathy scores and FA in the UF, and others identifying a positive relationship. Here, we investigated structural integrity of the left and right UF using fractional anisotropy (FA) in a large sample of n = 254 male adolescent offenders recruited from maximum-security juvenile correctional facilities. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV). Consistent with hypotheses, interpersonal and affective traits (i.e., PCL:YV Factor 1 and Facet 1 scores) were associated with reduced FA in the right UF. Additionally, lifestyle traits (i.e., PCL:YV Facet 3 scores) were associated with increased FA in the left UF. Results are consistent with previously published studies reporting reduced FA in the right UF in adult psychopathic offenders and increased left UF FA in youth meeting criteria for certain externalizing disorders.

Indexed as

AdolescentAntisocial Personality DisorderDiffusion Tensor ImagingHumansImage Interpretation, Computer-AssistedMaleUncinate FasciculusCallous-unemotional traitsDiffusion tensor imagingFractional anisotropyJuvenile delinquencyUncinate fasciculus

Identifiers

PMID32182577
PMCPMC7076567

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.