ArticleJournal of critical care2020
Impact of the pre-illness lipid profile on sepsis mortality.
Article in Journal of critical care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- The U-shaped relationship between triglyceride glucose-body mass index and prognosis of sepsis patients: a retrospective study.BMC infectious diseases · 2026Article
- High-density lipoprotein-cholesterol and triglyceride levels and their prognosis in critically ill septic patients.World journal of critical care medicine · 2026Article
- Association of triglyceride glucose index with sepsis risk after major abdominal surgery: A retrospective cohort study.Pakistan journal of medical sciences · 2025Article
- Association between blood triglycerides and stroke-associated pneumonia: a prospective cohort study.BMC neurology · 2025Article
- Triglyceride levels are associated with 30-day mortality in intensive care patients: a retrospective analysis in the MIMIC-IV database.European journal of medical research · 2024Article
- Article
- Predictive value of laboratory indicators for in-hospital death in children with community-onset sepsis: a prospective observational study of 266 patients.BMJ paediatrics open · 2024Observational
- The Utility of Serial Lipid Measurements as a Potential Predictor of Sepsis Outcome: A Prospective Observational Study in a Tertiary Care Hospital.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- U-shaped association between serum triglyceride levels and mortality among septic patients: An analysis based on the MIMIC-IV database.PloS one · 2023Article
- Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study.Annals of intensive care · 2021Article
- Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary Bypass.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo determine if baseline lipid levels contribute to the relationship between lipid levels during sepsis and outcomes. MATERIALS AND
methodsWe conducted a retrospective cohort study at a tertiary-care academic medical center. Multivariable logistic regression models were used to adjust for confounders. Both Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA) score-based definitions of sepsis were analyzed. MEASUREMENTS AND MAIN
resultsAfter adjusting for patient characteristics and severity of illness, baseline values for both low density lipoprotein (LDL) cholesterol and triglycerides were associated with mortality (LDL cholesterol odds ratio [OR] 0.44, 95% confidence interval [CI] 0.23-0.84, p = .013; triglyceride OR 0.54, 95% CI 0.37-0.78, p = .001) using a SIRS based definition of sepsis. An interaction existed between these two variables, which resulted in increased mortality with higher baseline low density lipoprotein (LDL) cholesterol values for individuals with triglycerides below 208 mg/dL and the opposite direction of association above this level (interaction OR 1.48, 95% CI 1.02-2.16, p = .039). When using a SOFA score-based definition, only triglycerides remained associated with the mortality (OR 0.55, 95% CI 0.35-0.86, p = .008).
conclusionsBaseline lipid values, particularly triglyceride concentrations, are associated with hospital mortality in septic patients.
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