ArticleAmerican journal of respiratory cell and molecular biology2020
Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling.
Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Xiebai San Alleviates Allergic Pulmonary Inflammation by Modulating Arachidonic Acid Metabolism.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Mechanism differences in the start time of sublingual immunotherapy in a mouse allergic airway inflammation model.Scientific reports · 2024Article
- Does Vitamin D Work Synergistically with Anti-Asthmatic Drugs in Airway Remodeling?International journal of molecular sciences · 2022Article
- Update in Adult Asthma 2020.American journal of respiratory and critical care medicine · 2021Review
- Asthma, atopy, and exercise: Sex differences in exercise-induced bronchoconstriction.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- The Intricate Web of Phospholipase AAmerican journal of respiratory cell and molecular biology · 2020Article
- Asthma: An Untoward Consequence of Endurance Sports?American journal of respiratory cell and molecular biology · 2020Article
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11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that the prevalence of asthma is higher in athletes, including Olympic athletes, than in the general population. In this study, we analyzed the mechanism of exercise-induced bronchoconstriction by using animal models of athlete asthma. Mice were made to exercise on a treadmill for a total duration of 1 week, 3 weeks, or 5 weeks. We analyzed airway responsiveness, BAL fluid, lung homogenates, and tissue histology for each period. In mice that were treated (i.e., the treatment model), treatments were administered from the fourth to the fifth week. We also collected induced sputum from human athletes with asthma and analyzed the supernatants. Airway responsiveness to methacholine was enhanced with repeated exercise stimulation, although the cell composition in BAL fluid did not change. Exercise induced hypertrophy of airway smooth muscle and subepithelial collagen deposition. Cysteinyl-leukotriene (Cys-LT) levels were significantly increased with exercise duration. Montelukast treatment significantly reduced airway hyperresponsiveness (AHR) and airway remodeling. Expression of PLA
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