ArticleGenome biology and evolution2020
The Limits to Estimating Population-Genetic Parameters with Temporal Data.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data.Genome biology and evolution · 2026Article
- Selection Estimation from Genetic Time-Series Data: Effects of Limited Sampling and Genetic Drift.Molecular biology and evolution · 2025Article
- The genome-wide signature of short-term temporal selection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evolutionary Insights from a Large-Scale Survey of Population-Genomic Variation.Molecular biology and evolution · 2023Article
- Article
- Evolutionary Insights from a Large-scale Survey of Population-genomic Variation.bioRxiv : the preprint server for biology · 2023Article
- Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression.The international journal of neuropsychopharmacology · 2023Article
- Recommendations for improving statistical inference in population genomics.PLoS biology · 2022Article
- Evolutionary Dynamics of Asexual Hypermutators Adapting to a Novel Environment.Genome biology and evolution · 2021Article
- Allele frequency divergence reveals ubiquitous influence of positive selection in Drosophila.PLoS genetics · 2021Article
- Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation ineLife · 2021Article
- Tapping Diversity From the Wild: From Sampling to Implementation.Frontiers in plant science · 2021Review
Corrections and comments
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2 authors.
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Abstract
The ability to obtain genome-wide sequences of very large numbers of individuals from natural populations raises questions about optimal sampling designs and the limits to extracting information on key population-genetic parameters from temporal-survey data. Methods are introduced for evaluating whether observed temporal fluctuations in allele frequencies are consistent with the hypothesis of random genetic drift, and expressions for the expected sampling variances for the relevant statistics are given in terms of sample sizes and numbers. Estimation methods and aspects of statistical reliability are also presented for the mean and temporal variance of selection coefficients. For nucleotide sites that pass the test of neutrality, the current effective population size can be estimated by a method of moments, and expressions for its sampling variance provide insight into the degree to which such methodology can yield meaningful results under alternative sampling schemes. Finally, some caveats are raised regarding the use of the temporal covariance of allele-frequency change to infer selection. Taken together, these results provide a statistical view of the limits to population-genetic inference in even the simplest case of a closed population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.