ArticleeLife2020
Short-term modulation of the lesioned language network.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia.CNS neuroscience & therapeutics · 2024Trial
- Probing the role of left inferior frontal gyrus in vocal motor control: Evidence from TMS and causal inference analysis.iScience · 2026Article
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.Annals of clinical and translational neurology · 2026Article
- Dynamic reorganization of task-related network interactions in post-stroke aphasia recovery.Brain : a journal of neurology · 2025Article
- Inhibition of the inferior parietal lobe triggers state-dependent network adaptations.Heliyon · 2024Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Bilateral human laryngeal motor cortex in perceptual decision of lexical tone and voicing of consonant.Nature communications · 2023Article
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia.Brain and language · 2022Article
- Preparing for a Second Attack: A Lesion Simulation Study on Network Resilience After Stroke.Stroke · 2022Article
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- Dissociable contributions of frontal and temporal brain regions to basic semantic composition.Brain communications · 2021Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing.Neurobiology of language (Cambridge, Mass.) · 2021Article
- The Role of the Right Hemisphere White Matter Tracts in Chronic Aphasic Patients After Damage of the Language Tracts in the Left Hemisphere.Frontiers in human neuroscience · 2021Article
- Variables and Mechanisms Affecting Response to Language Treatment in Multilingual People with Aphasia.Behavioral sciences (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Language is sustained by large-scale networks in the human brain. Stroke often severely affects function and network dynamics. However, the adaptive potential of the brain to compensate for lesions is poorly understood. A key question is whether upregulation of the right hemisphere is adaptive for language recovery. Targeting the potential for short-term reorganization in the lesioned brain, we applied 'virtual lesions' over left anterior or posterior inferior frontal gyrus (IFG) in post-stroke patients with left temporo-parietal lesions prior to functional neuroimaging. Perturbation of the posterior IFG selectively delayed phonological decisions and decreased phonological activity. The individual response delay was correlated with the upregulation of the lesion homologue, likely reflecting compensation. Moreover, stronger individual tract integrity of the right superior longitudinal fascicle was associated with lesser disruption. Our results provide evidence for functional and structural underpinnings of plasticity in the lesioned language network, and a compensatory role of the right hemisphere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.