ArticleBioactive materials2020
In vitro degradation of pure magnesium-the synergetic influences of glucose and albumin.
Article in Bioactive materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo.Acta biomaterialia · 2026Article
- Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment.Scientific reports · 2025Article
- Degradation behavior of porous magnesium alloy scaffold under the low-intensity pulsed ultrasound intervention and their effect on bone defects repair.Regenerative biomaterials · 2025Article
- Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications.Bioactive materials · 2024Review
- An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion.Bioactive materials · 2024Review
- Preparation of HA-MAO coatings on β-type alloys and its corrosion resistance in high glucose environments.RSC advances · 2024Article
- Albumin Protein Impact on Early-StageACS applied materials & interfaces · 2024Article
- Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals.Regenerative biomaterials · 2024Article
- Development of a Bioreactor-Coupled Flow-Cell Setup for 3D In Situ Nanotomography of Mg Alloy Biodegradation.ACS applied materials & interfaces · 2023Article
- Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications: Concept and proof.Bioactive materials · 2023Article
- Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation.Bioactive materials · 2023Review
- Current status and outlook of potential applications of biodegradable materials in cerebral vascular stents.Neurosurgical review · 2022Review
- Morphological and Surface Potential Characterization of Protein Nanobiofilm Formation on Magnesium Alloy Oxide: Their Role in Biodegradation.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Biodegradable Magnesium Biomaterials-Road to the Clinic.Bioengineering (Basel, Switzerland) · 2022Review
- The effect of enzymes on the in vitro degradation behavior of Mg alloy wires in simulated gastric fluid and intestinal fluid.Bioactive materials · 2022Article
- Advances in coatings on magnesium alloys for cardiovascular stents - A review.Bioactive materials · 2021Review
- Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction.Bioactive materials · 2021Review
- Microbial ingress andBioactive materials · 2020Article
- Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility.Bioactive materials · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo, particularly, in the microenvironment of the patients with hyperglycemia or diabetes. Thus, we explored the synergistic effects of glucose and protein on the biodegradation of pure magnesium, so as to have a deeper understanding the mechanism of the degradation in vivo. The surface morphology and corrosion product composition of pure magnesium were investigated using SEM, EDS, FTIR, XRD and XPS. The effect of glucose and albumin on the degradation rate of pure magnesium was investigated via electrochemical and immersion tests. The adsorption of glucose and albumin on the sample surface was observed using fluorescence microscopy. The results showed that the presence of 2 g/L glucose changed the micromorphology of corrosion products on the magnesium surface by reacting with metal cations, thus inhibiting the corrosion of pure magnesium. Protein formed a barrier layer to protect the magnesium at early stage of immersion. The chelation reaction between protein and magnesium surface might accelerate the degradation at later stage. There may be a critical glucose (albumin) content. Biodegradation of pure magnesium was inhibited at low concentrations and promoted at high concentrations. The synergistic effect of glucose and protein restrained the adsorption of aggressive chloride ions to a certain extent, and thus inhibited the degradation of pure magnesium considerably. Moreover, XPS results indicated that glucose promoted the adsorption of protein on the sample surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.