ReviewFrontiers in nutrition2020
Time-of-Day-Dependent Physiological Responses to Meal and Exercise.
Review in Frontiers in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis.Sports medicine - open · 2023Pooled it
- Trial
- Trial
- Trial
- Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study.European journal of clinical nutrition · 2023Trial
- Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men.Physiological reports · 2021Trial
- Ubiquitous Sirt1 overexpression is associated with preserved cardiac diastolic function and mitochondrial respiratory capacity in mice on a high-fat diet.Metabolism open · 2026Article
- The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes.Diabetologia · 2026Review
- Associations between temporal meal patterns, cardiovascular risk factors and cardiovascular disease in Swedish adults: cross-sectional and nested case-control analyses.European journal of nutrition · 2026Article
- The Gastro-Circadian Metabolic Axis: A Comprehensive Framework for Chronotherapy in Gastroenterology.Cureus · 2026Review
- Optimal nap timing and body mass index: beyond duration.Journal of translational medicine · 2026Observational
- Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Training-Fuel Coupling (TFC): A Molecular Sports Nutrition Framework for Energy Availability, Chrono-Nutrition, and Performance Optimization.Nutrients · 2026Review
- Temporal meal patterns in relation to diet quality and body mass index: findings from a cross-sectional analysis.European journal of nutrition · 2025Article
- Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Self selected music during warm up improves anaerobic performance in female handball players across time of day.Scientific reports · 2025Article
- Diurnal timing and volume of physical activity in relation to metabolic syndrome in US adults: a population-based cohort study.International journal of obesity (2005) · 2025Article
- Circadian nutrition and obesity: timing as a nutritional strategy.Journal of health, population, and nutrition · 2025Review
- Time-restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex-dependent study.The Journal of physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian circadian clock drives the temporal coordination in cellular homeostasis and it leads the day-night fluctuation of physiological functions, such as sleep/wake cycle, hormonal secretion, and body temperature. The mammalian circadian clock system in the body is classified hierarchically into two classes, the central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and the peripheral clocks in peripheral tissues such as the intestine and liver, as well as other brain areas outside the SCN. The circadian rhythm of various tissue-specific functions is mainly controlled by each peripheral clock and partially by the central clock as well. The digestive, absorptive, and metabolic capacities of nutrients also show the day-night variations in several peripheral tissues such as small intestine and liver. It is therefore indicated that the bioavailability or metabolic capacity of nutrients depends on the time of day. In fact, the postprandial response of blood triacylglycerol to a specific diet and glucose tolerance exhibit clear time-of-day effects. Meal frequency and distribution within a day are highly related to metabolic functions, and optimal time-restricted feeding has the potential to prevent several metabolic dysfunctions. In this review, we summarize the time-of-day-dependent postprandial response of macronutrients to each meal and the involvement of circadian clock system in the time-of-day effect. Furthermore, the chronic beneficial and adverse effects of meal time and eating pattern on metabolism and its related diseases are discussed. Finally, we discuss the timing-dependent effects of exercise on the day-night variation of exercise performance and therapeutic potential of time-controlled-exercise for promoting general health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.