Evidence map›Paper›PMID 32181141›Full record

ArticleMolecular genetics and metabolism reports2020

Executive functioning, adaptive skills, emotional and behavioral profile: A comparison between autism spectrum disorder and phenylketonuria.

Barbara Trimarco, Filippo Manti, Francesca Nardecchia, Sergio Melogno, Mara Testa, Giovanni Meledandri, Claudia Carducci, Roberta Penge, Vincenzo Leuzzi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Barbara TrimarcoDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Filippo MantiDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Francesca NardecchiaDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Sergio MelognoDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Mara TestaDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Giovanni MeledandriDepartment of Human Science, "Università degli Studi Guglielmo Marconi", Via Plinio 44, 00193 Rome, Italy.
Claudia CarducciDepartment of Experimental Medicine, Sapienza University of Rome, Viale del policlinico 155, 00161 Rome, Italy.
Roberta PengeDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Vincenzo LeuzziDepartment of Human Neuroscience, "Sapienza" University of Rome, Via dei Sabelli 108, 00185 Rome, Italy.
Sapienza University of Rome · ITMarconi University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfluential theories maintain that some of Autism Spectrum Disorder (ASD) core symptoms may arise from deficits in executive functions (EF). EF deficits are also considered a neuropsychological marker of early treated individuals with phenylketonuria (PKU). Aims of this study were: to verify the occurrence and patterns of specific EF impairments in both clinical groups; to explore the coexistence of EF alterations with adaptive, behavioral and emotional problems in each clinical condition. MATERIAL AND

methodsWe assessed EF, adaptive, behavioral and emotional profile in 21 participants with ASD, 15 early treated PKU individuals, comparable for age and IQ, and 14 controls, comparable for age to the clinical groups (age range: 7-14 years).

resultsASD and PKU participants presented two different, but partially overlapping patterns of EF impairment. While ASD participants showed a specific deficit in cognitive flexibility only, PKU individuals showed a more extensive impairment in EF with a weaker performance in two core EF domains (inhibition, cognitive flexibility) as compared to healthy controls. Psychological and adaptive profile was typical in PKU participants, while ASD participants experienced behavioral (externalizing symptoms), emotional (internalizing symptoms) and adaptive disorders (general, practical, social domains).

conclusionsPresent results support the view of a relative disengagement of adaptive and emotional-behavioral profile with respect to EF skills and suggest that other dysfunctions contribute to the multidimensional phenotype of ASD participants.

Indexed as

Adaptive behaviorAutism spectrum disorderExecutive functionsInternalizing and externalizing symptomsPhenylketonuria

Identifiers

PMID32181141
PMCPMC7066217
OpenAlexW3011778219

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.