Evidence map›Paper›PMID 32180916›Full record

ArticleMedChemComm2019

Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities.

Di Ge, Lina Han, Feifei Yang, Na Zhao, Yang Yang, Hua Zhang, Yihua Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Di GeSchool of Biological Science and Technology , University of Jinan , Jinan , Shandong Province 250022 , China . Email: yee68511@126.com ; Email: bio_zhangh@ujn.edu.cn.
Lina HanSchool of Biological Science and Technology , University of Jinan , Jinan , Shandong Province 250022 , China . Email: yee68511@126.com ; Email: bio_zhangh@ujn.edu.cn.
Feifei YangSchool of Biological Science and Technology , University of Jinan , Jinan , Shandong Province 250022 , China . Email: yee68511@126.com ; Email: bio_zhangh@ujn.edu.cn.ORCID 0000-0001-9362-7635
Na ZhaoSchool of Biological Science and Technology , University of Jinan , Jinan , Shandong Province 250022 , China . Email: yee68511@126.com ; Email: bio_zhangh@ujn.edu.cn.
Yang YangShanghai Key Laboratory of Regulatory Biology , The Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , Shanghai , 200241 , China . Email: yhchen@bio.ecnu.edu.cn.
Hua ZhangSchool of Biological Science and Technology , University of Jinan , Jinan , Shandong Province 250022 , China . Email: yee68511@126.com ; Email: bio_zhangh@ujn.edu.cn.ORCID 0000-0002-5959-6473
Yihua ChenShanghai Key Laboratory of Regulatory Biology , The Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , Shanghai , 200241 , China . Email: yhchen@bio.ecnu.edu.cn.ORCID 0000-0003-1733-7980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we designed and synthesized a series of bis-substituted aromatic amide-based histone deacetylase (HDAC) inhibitors. In this study, we report the replacement of a bromine atom by different amides on the phenyl ring of the CAP region. Representative compounds

Identifiers

PMID32180916
PMCPMC7053699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.