ReviewFrontiers in immunology2020
Machine Perfusion of Extended Criteria Donor Organs: Immunological Aspects.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine Perfusion in Liver Transplantation: A Systematic Review and Meta-Analysis.Visceral medicine · 2022Pooled it
- Comparison of Normothermic and Subnormothermic Machine Perfusion of Porcine Kidneys Using a Novel Fully Synthetic Perfusion Solution: A Proof-of-Concept Study.Journal of clinical medicine · 2026Article
- Impact of Hypothermic Perfusion on Immune Responses and Sterile Inflammation in a Preclinical Model of Pancreatic Transplantation.Transplantation direct · 2025Article
- The Evolution of Kidney Graft Preservation Through the Years.Life (Basel, Switzerland) · 2024Review
- Evaluation of the advanced air mobility potential for organ transplantation in Austria and Germany.Scientific reports · 2024Article
- Combined Organ Transplantation in Patients with Advanced Liver Disease.Seminars in liver disease · 2024Review
- Review
- Biliary and Vascular Complications after Liver Transplantation-From Diagnosis to Treatment.Medicina (Kaunas, Lithuania) · 2023Review
- Sterile Pancreas Inflammation during Preservation and after Transplantation.International journal of molecular sciences · 2023Review
- Novel, Innovative Models to Study Ischemia/Reperfusion-Related Redox Damage in Organ Transplantation.Antioxidants (Basel, Switzerland) · 2022Review
- The significance of the first living donor kidney transplantation in Jeju: a case report.Korean journal of transplantation · 2022Article
- Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys.Frontiers in immunology · 2022Article
- α1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts.Respiratory research · 2021Article
- Assessment of Oxidative Stress Markers in Hypothermic Preservation of Transplanted Kidneys.Antioxidants (Basel, Switzerland) · 2021Article
- Melatonin and Glycine Reduce Uterus Ischemia/Reperfusion Injury in a Rat Model of Warm Ischemia.International journal of molecular sciences · 2021Article
- The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion.Biomedicines · 2021Article
- Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials.Frontiers in immunology · 2021Review
- Impact of Graft-Resident Leucocytes on Treg Mediated Skin Graft Survival.Frontiers in immunology · 2021Article
- The Role of Metabolomics in Current Concepts of Organ Preservation.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to higher vulnerability and immunogenicity of extended criteria donor (ECD) organs used for organ transplantation (Tx), the discovery of new treatment strategies, involving tissue allorecognition pathways, is important. The implementation of machine perfusion (MP) led to improved estimation of the organ quality and introduced the possibility to achieve graft reconditioning prior to Tx. A significant number of experimental and clinical trials demonstrated increasing support for MP as a promising method of ECD organ preservation compared to classical static cold storage. MP reduced ischemia-reperfusion injury resulting in the protection from inadequate activation of innate immunity. However, there are no general agreements on MP protocols, and clinical application is limited. The objective of this comprehensive review is to summarize literature on immunological effects of MP of ECD organs based on experimental studies and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.