ArticleFrontiers in molecular neuroscience2020
Probing Cortical Activity During Head-Fixed Behavior.
Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026Article
- Article
- Divergent subregional information processing in mouse prefrontal cortex during working memory.Communications biology · 2024Article
- Divergent Subregional Information Processing in Mouse Prefrontal Cortex During Working Memory.bioRxiv : the preprint server for biology · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- An automated, low-latency environment for studying the neural basis of behavior in freely moving rats.BMC biology · 2023Article
- Article
- Article
- An Open-Source Platform for Head-Fixed Operant and Consummatory Behavior.bioRxiv : the preprint server for biology · 2023Article
- A flexible Python-based touchscreen chamber for operant conditioning reveals improved visual perception of cardinal orientations in mice.Frontiers in cellular neuroscience · 2022Article
- A Novel Device of Reaching, Grasping, and Retrieving Task for Head-Fixed Mice.Frontiers in neural circuits · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cortex is crucial for many behaviors, ranging from sensory-based behaviors to working memory and social behaviors. To gain an in-depth understanding of the contribution to these behaviors, cellular and sub-cellular recordings from both individual and populations of cortical neurons are vital. However, techniques allowing such recordings, such as two-photon imaging and whole-cell electrophysiology, require absolute stability of the head, a requirement not often fulfilled in freely moving animals. Here, we review and compare behavioral paradigms that have been developed and adapted for the head-fixed preparation, which together offer the needed stability for live recordings of neural activity in behaving animals. We also review how the head-fixed preparation has been used to explore the function of primary sensory cortices, posterior parietal cortex (PPC) and anterior lateral motor (ALM) cortex in sensory-based behavioral tasks, while also discussing the considerations of performing such recordings. Overall, this review highlights the head-fixed preparation as allowing in-depth investigation into the neural activity underlying behaviors by providing highly controllable settings for precise stimuli presentation which can be combined with behavioral paradigms ranging from simple sensory detection tasks to complex, cross-modal, memory-guided decision-making tasks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.