ArticleMolecular metabolism2020
A Neural basis for Octanoic acid regulation of energy balance.
Article in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Medium-chain fatty acid-rich oils with varying free fatty acid levels as alternatives to soybean oil in broiler starter diets.Poultry science · 2026Article
- Octanoic acid treatment alleviates cold-induced depression-like behaviors via targeting the AKR1B1-PGF2α pathway.iScience · 2026Article
- Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms.Journal of neuroendocrinology · 2026Article
- The Effect of Alkyl Chain Length on Biofunction of Dietary Lipid.Molecules (Basel, Switzerland) · 2026Review
- Metabolic Astrocytic Support with Decanoic Acid Enhances Energy Metabolism in Alzheimer's Disease Models.Cells · 2025Article
- Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals.Molecular metabolism · 2025Article
- Octanoic acid-rich diet alleviates breast cancer-induced bone pain via the acyl-ghrelin/NPY pathway.The Korean journal of pain · 2025Article
- Effect of 8-Methyl Nonanoic Acid, a Degradation By-Product of Dihydrocapsaicin, on Energy and Glucose Homeostasis in Diet-Induced Obese Mice.Journal of experimental pharmacology · 2025Article
- Untargeted Metabolite Profiling Reveals Acute Toxicity of Pentosidine on Adipose Tissue of Rats.Metabolites · 2024Article
- Octanoic acid mitigates busulfan-induced blood-testis barrier damage by alleviating oxidative stress and autophagy.Lipids in health and disease · 2024Article
- Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food.PLoS biology · 2024Article
- Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice.Molecular metabolism · 2023Article
- Impact of dietary fat levels and fatty acid composition on milk fat synthesis in sows at peak lactation.Journal of animal science and biotechnology · 2023Article
- Article
- Effects of supplemental octanoate on hepatic lipid metabolism, serum biochemical indexes, antioxidant capacity and inflammation-related genes expression of large yellow croaker (Frontiers in immunology · 2023Article
- Acylation, a Conductor of Ghrelin Function in Brain Health and Disease.Frontiers in physiology · 2022Review
- Supplementation of Regular Diet With Medium-Chain Triglycerides for Procognitive Effects: A Narrative Review.Frontiers in nutrition · 2022Review
- Purinergic signaling in tanycytes and its contribution to nutritional sensing.Purinergic signalling · 2021Review
- Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply.Molecular brain · 2021Article
- The Ketogenic Effect of Medium-Chain Triacylglycerides.Frontiers in nutrition · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the mechanisms by which they regulate activity of hypothalamic neurons.
methodsSimultaneous blood and cerebrospinal fluid (CSF) sampling was undertaken in rats and metabolic analyses using radiolabeled fatty acid tracers were performed on mice. Electrophysiological recording techniques were used to investigate signaling mechanisms underlying fatty acid-induced changes in activity of pro-opiomelanocortin (POMC) neurons.
resultsMedium-chain fatty acid (MCFA) octanoic acid (C8:0), unlike long-chain fatty acids, was rapidly transported into the hypothalamus of mice and almost exclusively oxidized, causing rapid, transient reductions in food intake and increased energy expenditure. Octanoic acid differentially regulates the excitability of POMC neurons, activating these neurons directly via GPR40 and inducing inhibition via an indirect non-synaptic, purine, and adenosine receptor-dependent mechanism.
conclusionsMCFA octanoic acid is a central signaling nutrient that targets POMC neurons via distinct direct and indirect signal transduction pathways to instigate changes in energy status. These results could explain the beneficial health effects that accompany MCFA consumption.
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