ArticleMolecular metabolism2020
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation.
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Article in Molecular metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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21 citing papers in PubMed, 26 citations in OpenAlex.
- ERα/SIRT1 signaling mediates the metabolic regulatory benefits of pterostilbene.The Journal of biological chemistry · 2026Article
- Pre-Treatment with Estradiol, But not Progesterone, Exacerbates DSS Colitis: Dysregulated Innate Immunity and Impaired Epithelial Damage Response.Inflammation · 2026Article
- hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.Stem cell research & therapy · 2025Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- The Estrogen-Autophagy Axis: Insights into Cytoprotection and Therapeutic Potential in Cancer and Infection.International journal of molecular sciences · 2024Review
- Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry.Journal of visualized experiments : JoVE · 2024Article
- Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy.Nature reviews. Endocrinology · 2024Review
- Article
- Nuclear receptors as potential therapeutic targets in peripheral arterial disease and related myopathy.The FEBS journal · 2023Review
- Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male Mice.Endocrinology · 2023Article
- Pre- and Post-Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function.Journal of the Endocrine Society · 2023Article
- Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen.Clinical science (London, England : 1979) · 2023Review
- Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.Nature cardiovascular research · 2023Article
- In vivo potentiation of muscle torque is enhanced in female mice through estradiol-estrogen receptor signaling.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function.Sports medicine (Auckland, N.Z.) · 2022Review
- Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?Journal of the Endocrine Society · 2022Review
- The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Skeletal muscle wasting: the estrogen side of sexual dimorphism.American journal of physiology. Cell physiology · 2022Review
- Interactions between estradiol, diabetes, and brain aging and the risk for cognitive impairment.Climacteric : the journal of the International Menopause Society · 2021Review
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Authors and funding
26 authors at 4 institutions in 1 country.
Melissa R IñigoEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA.
Adam J AmoreseEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA.
Michael D TarpeyEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA.
Nicholas P BalestrieriEast Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA.
Keith G JonesEast Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA.
Daniel J PattesonEast Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA.
Kathryn C JacksonUniversity of Maryland, School of Public Health, Department of Kinesiology, College Park, MD, USA.
Maria J TorresEast Carolina University, Department of Kinesiology, Greenville, NC, USA.
Chien-Te LinEast Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA.
Cody D SmithEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA.
Timothy D HedenEast Carolina University, Department of Kinesiology, Greenville, NC, USA.
Shawna L McMillinEast Carolina University, Department of Kinesiology, Greenville, NC, USA.
Luke A WeyrauchEast Carolina University, Department of Kinesiology, Greenville, NC, USA.
Erin C StanleyEast Carolina University, Department of Kinesiology, Greenville, NC, USA.
Cameron A SchmidtEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA.
Brita B Kilburg-BasnyatEast Carolina University Brody School of Medicine, Department of Pharmacology and Toxicology, Greenville, NC, USA.
Sky W ReeceEast Carolina University Brody School of Medicine, Department of Pharmacology and Toxicology, Greenville, NC, USA.
Christine E PsaltisEast Carolina University Brody School of Medicine, Department of Pharmacology and Toxicology, Greenville, NC, USA.
Leslie A LeinwandUniversity of Colorado, Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, Boulder, CO, USA.
Katsuhiko FunaiEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA; East Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA; East Carolina University, Department of Kinesiology, Greenville, NC, USA.
Joseph M McClungEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA; East Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA.
Kymberly M GowdyEast Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA; East Carolina University Brody School of Medicine, Department of Pharmacology and Toxicology, Greenville, NC, USA.
Carol A WitczakEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA; East Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA; East Carolina University, Department of Kinesiology, Greenville, NC, USA; East Carolina University, Department of Biochemistry and Molecular Biology, Greenville, NC, USA.
Dawn A LoweUniversity of Minnesota, Department of Rehabilitation Medicine, Division of Rehabilitation Science and Division of Physical Therapy, Minneapolis, MN, USA.
P Darrell NeuferEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA; East Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA; East Carolina University, Department of Kinesiology, Greenville, NC, USA.
Espen E SpangenburgEast Carolina University Brody School of Medicine, Department of Physiology, Greenville, NC, USA; East Carolina University, East Carolina Diabetes and Obesity Institute, Greenville, NC, USA; East Carolina University, Department of Kinesiology, Greenville, NC, USA. Electronic address: spangenburge14@ecu.edu.
East Carolina University · USUniversity of Colorado Boulder · USUniversity of Maryland, College Park · USUniversity of Minnesota · US
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MMYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3MInteratction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4MPE methylation in skeletal muscle energy efficiencyR01DK107397 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2017 to 2025
$3.8MGenetic Determinants of Limb Pathology in Peripheral Artery DiseaseR01HL125695 · NHLBI · EAST CAROLINA UNIVERSITY · PI MCCLUNG, JOSEPH MATTHEW · 2015 to 2019
$1.9MCalmodulin Kinases and Control of Skeletal Muscle Glucose MetabolismR01DK103562 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI WITCZAK, CAROL ANN · 2015 to 2019
$1.7MBRCA1 is necessary for optimal skeletal muscle functionR01AR066660 · NIAMS · EAST CAROLINA UNIVERSITY · PI SPANGENBURG, ESPEN E · 2015 to 2019
$1.6MRedox Biology and Muscle Insulin SensitivityR01DK096907 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2012 to 2015
$1.4MMitochondrial phospholipids, ROS, and disuse atrophyR21AG063077 · NIA · UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2019 to 2020
$419kSupplement to DK109888R03DK109888 · NIDDK · UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2016 to 2017
$208kSkeletal muscle mitochondrial phosphatidylethanolamine and respiratorycapacityF32DK109556 · NIDDK · UNIVERSITY OF MINNESOTA · PI HEDEN, TIMOTHY D. · 2016 to 2018
$118kNHLBI NIH HHS R01 HL125695NIAMS NIH HHS R01 AR066660NIA NIH HHS R01 AG031743NIA NIH HHS R21 AG063077NIDDK NIH HHS F32 DK109556NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK096907NIDDK NIH HHS R01 DK103562NIDDK NIH HHS R01 DK107397NIDDK NIH HHS R03 DK109888NIGMS NIH HHS R01 GM029090
Abstract
objectiveEstrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skeletal muscle were confounded by altered developmental programming and/or influenced by secondary effects, making it difficult to assign a causal role for ERα. The objective of this study was to determine the role of skeletal muscle ERα in regulating metabolism in the absence of confounding factors of development.
methodsA novel mouse model was developed allowing for induced deletion of ERα in adult female skeletal muscle (ERαKO
resultsTwelve weeks of HFD exposure had no differential effects on body composition, VO
conclusionsCollectively, these results suggest that ERα function is superfluous in protecting against HFD-induced skeletal muscle metabolic derangements after postnatal development is complete.
Indexed as
AnimalsEstrogen Receptor alphaFemaleHumansInsulinMiceMice, KnockoutMitochondriaMuscle, SkeletalESR1 protein, humanEstrogen Receptor alphaInsulinEstrogen receptor-alphaInflammationInsulin sensitivityMetabolismMitochondrial functionSkeletal muscle
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