Evidence map›Paper›PMID 32180548›Full record

ArticleeLife2020

Molecular basis for catabolism of the abundant metabolite

Lindsey Rf Backman, Yolanda Y Huang, Mary C Andorfer, Brian Gold, Ronald T Raines, Emily P Balskus, Catherine L Drennan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. The structural basis of malodorant skatole formation by the glycyl radical enzyme indoleacetate decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Marine life science & technology · 2025
    Article
  8. Article
  9. Article
  10. Development of aniScience · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lindsey Rf Backman *Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-0323-1336
Yolanda Y Huang *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-1263-1515
Mary C AndorferDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0003-3406-2341
Brian GoldDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-3534-1329
Ronald T RainesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-7164-1719
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, United States.ORCID 0000-0001-5985-5714
Catherine L DrennanDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-5486-2755
Massachusetts Institute of Technology · USHarvard University · USHoward Hughes Medical Institute · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ENGELWARD, BEVIN P. · 1985 to 2020
$25.6M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Metalloenzyme structure, function and assemblyR35GM126982 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CATHERINE L DRENNAN · 2018 to 2026
$3.4M
Complex Metallocluster Structure and AssemblyR01GM069857 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DRENNAN, CATHERINE L · 2004 to 2017
$3.1M
Chemistry and Biology of CollagenR56AR044276 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RAINES, RONALD T · 2019 to 2020
$826k
Taming radical enzymes through directed evolution and structural analysisF32GM129882 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANDORFER, MARY CATHERINE · 2018 to 2021
$193k
Howard Hughes Medical InstituteNIAMS NIH HHS R56 AR044276NIEHS NIH HHS P30 ES002109NIGMS NIH HHS F32 GM129882NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM069857NIGMS NIH HHS R35 GM126982NIH HHS R56 AR044276
6 · The paper itself

Abstract

The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE,

Indexed as

Clostridioides difficileGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicHydroxyprolineModels, MolecularProlineProtein ConformationProteinsHydroxyprolineHypD protein, BacteriaProlineProteinstrans-4-hydroxy-L-prolinebiochemistryC. difficilechemical biologyE. coliglycyl radical enzymegut microbiomehydroxyprolinemolecular biophysicsradical chemistrystructural biology

Identifiers

PMID32180548
PMCPMC7077986
OpenAlexW3011494154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.