ArticleAmerican journal of Alzheimer's disease and other dementias
Insulin Resistance Is Independently Associated With Enlarged Perivascular Space in the Basal Ganglia in Nondiabetic Healthy Elderly Population.
Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Insulin resistance in cerebral small vessel disease: a mini review.Frontiers in neuroscience · 2026Review
- Whispering Through the Barrier: Signaling Interfaces for Peripheral Regulation of Brain Function in Obesity.Journal of neurochemistry · 2025Review
- Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals.Aging medicine (Milton (N.S.W)) · 2025Article
- Enlarged perivascular spaces in the basal ganglia mediate the negative impact of HbA1c levels on mild cognitive impairment.Frontiers in human neuroscience · 2025Article
- Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease.Frontiers in aging neuroscience · 2025Article
- Brain endothelial cell activation and dysfunction associate with and contribute to the development of enlarged perivascular spaces and cerebral small vessel disease.Histology and histopathology · 2024Review
- Spatial Similarity of MRI-Visible Perivascular Spaces in Healthy Young Adult Twins.Yonsei medical journal · 2024Article
- Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.NPJ microgravity · 2024Article
- A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus.Biomedicines · 2024Review
- Brain Injury: Response to Injury Wound-Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2023Review
- Brain Endothelial Cells Play a Central Role in the Development of Enlarged Perivascular Spaces in the Metabolic Syndrome.Medicina (Kaunas, Lithuania) · 2023Review
- Insulin resistance, cognition, and Alzheimer disease.Obesity (Silver Spring, Md.) · 2023Review
- Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI.Journal of magnetic resonance imaging : JMRI · 2023Review
- Insulin resistance based on postglucose load measure is associated with prevalence and burden of cerebral small vessel disease.BMJ open diabetes research & care · 2022Article
- The Triglyceride Glucose Index Is a Risk Factor for Enlarged Perivascular Space.Frontiers in neurology · 2022Article
- Enlarged perivascular spaces in subcortical white matter are linked to amyloid-tau depositions and cognitive decline: Data from a memory clinic in Thailand.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population.
methodsA total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) was used for IR estimation. Correlation between IR and severity of EPVS was assessed using the regression model after adjusting demographics and cardiovascular risk factors.
resultsThe top quartile of HOMA-IR was 2.52, and 25.11% of patients showed IR. The proportion of patients with IR was higher in the moderate to severe EPVS group than in the mild group (36.51% vs 20.93%,
conclusionsInsulin resistance was independently correlated with EPVS in the basal ganglia in nondiabetic healthy elderly population.
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