SynthesisOrthopaedic surgery2020
Autografts vs Synthetics for Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.
Synthesis in Orthopaedic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Patellar tendon versus artificial grafts in anterior cruciate ligament reconstruction: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Clinical results after arthroscopic reconstruction of the posterolateral corner of the knee: A prospective randomized trial comparing two different surgical techniques.Archives of orthopaedic and trauma surgery · 2023Trial
- Comparative analysis of autograftJournal of spine surgery (Hong Kong) · 2026Article
- Patient-reported outcomes after anterior cruciate ligament reconstruction with the JewelACL synthetic ligament: Multicenter study of at least 9 years follow-up.Journal of experimental orthopaedics · 2026Review
- All-Inside Primary Anterior Cruciate Ligament Reconstruction Using a Combined Polyester Synthetic Graft and Gracilis Tendon Autograft: Modified Technique of a Hybrid 4 × 2 Graft Preparation.Arthroscopy techniques · 2026Article
- Revision ACL reconstruction guided by 3D printed preoperative templating: comparison of outcomes between bone-patellar tendon-bone autograft and Ligament Augmentation and Reconstruction System (LARS) ligament.BMC musculoskeletal disorders · 2026Article
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- Effectiveness of synthetic vs. autologous ligaments in anterior cruciate ligament reconstruction with remnant preservation: a retrospective cohort study.Frontiers in sports and active living · 2026Article
- Single-Stage vs. Multi-Stage Reconstruction in Multi-Ligament Knee Injuries: A Systematic Review and Meta-Analysis of Outcomes and Complications.Journal of clinical medicine · 2025Review
- 8-11 year results of LARS augmented hamstring in anterior cruciate ligament reconstruction surgery: Incidence of synovitis and failures.Journal of orthopaedics · 2025Article
- Hamstring autograft, bone-patellar-tendon-bone autograft and synthetic graft in primary anterior cruciate ligament reconstruction: A meta-analysis of comparative studies.Journal of experimental orthopaedics · 2025Review
- Through-tunnel reconstruction with Ligament Augmentation and Reconstruction System (LARS) for managing post-arthroplasty patellofemoral instability.BMC musculoskeletal disorders · 2025Article
- Anterior Cruciate Ligament Reconstruction with LARS Synthetic Ligament: Outcomes and Failures.Journal of clinical medicine · 2024Article
- A Modern-Day Algorithm for the Treatment of Multi-Ligament Knee Injuries.Indian journal of orthopaedics · 2024Article
- The in vitro elution characteristics of vancomycin from the ligament augmentation and reconstruction system.Journal of experimental orthopaedics · 2024Article
- Synthetic Grafts in Anterior Cruciate Ligament Reconstruction Surgery in Professional Female Handball Players-A Viable Option?Diagnostics (Basel, Switzerland) · 2024Article
- Anatomic Double-Bundle Transtibial Anterior Cruciate Ligament Reconstruction With Ligament Advanced Reinforcement System.Arthroscopy techniques · 2024Article
- Intra-Articular Surgical Reconstruction of a Canine Cranial Cruciate Ligament Using an Ultra-High-Molecular-Weight Polyethylene Ligament: Case Report with Six-Month Clinical Outcome.Veterinary sciences · 2024Article
- Morphometry of the patellar tendon using a simple tracing method: a gold standard for anterior cruciate ligament reconstruction.Anatomy & cell biology · 2023Article
- Subcortical Backup Tibial Fixation in Anterior Cruciate Ligament Reconstruction Has Similar Maximal Strength to Current Techniques.Arthroscopy, sports medicine, and rehabilitation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
To describe the outcomes of autografts and synthetics in anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction with respect to instrumented laxity measurements, patient-reported outcome scores, complications, and graft failure risk. We searched PubMed, Cochrane Library, and EMBASE for published randomized controlled trials (RCT) and case controlled trials (CCTs) to compare the outcomes of the autografts versus synthetics after cruciate ligament reconstruction. Data analyses were performed using Cochrane Collaboration RevMan 5.0. Nine studies were identified from the literature review. Of these studies, three studies compared the results of bone-patellar tendon-bone (BPTB) and ligament augmentation and reconstruction system (LARS), while six studies compared the results of four-strand hamstring tendon graft (4SHG) and LARS. The comparative study showed no difference in Lysholm score and failure risk between autografts and synthetics. The combined results of the meta-analysis indicated that there was a significantly lower rate of side-to-side difference > 3 mm (Odds Ratio [OR] 2.46, 95% confidence intervals [CI] 1.44-4.22, P = 0.001), overall IKDC (OR 0.40, 95% CI 0.19-0.83, P = 0.01), complications (OR 2.54, 95% CI 1.26-5.14, P = 0.009), and Tegner score (OR -0.31, 95% CI -0.52-0.10, P = 0.004) in the synthetics group than in the autografts group. This systematic review comparing long-term outcomes after cruciate ligament reconstruction with either autograft or synthetics suggests no significant differences in failure risk. Autografts were inferior to synthetics with respect to restoring knee joint stability and patient-reported outcome scores, and were also associated with more postoperative complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.