ArticleAngewandte Chemie (International ed. in English)2020
Conditional Copper-Catalyzed Azide-Alkyne Cycloaddition by Catalyst Encapsulation.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines.Nature communications · 2026Article
- Droplet-mediated kinetic-to-thermodynamic transition for the fabrication of uniform 1D and 2D nanostructures from conjugated homopolymers.Chemical science · 2026Article
- Supramolecular Materials and Strategies for Bioorthogonal Chemical Transformations.Chemical reviews · 2025Review
- Transient Host-Guest Complexation To Control Catalytic Activity.Journal of the American Chemical Society · 2022Article
- Cooperative Effects in Switchable Catalysis: Enhancing Double-Click Reaction Yield of Symmetrical Rotaxanes.Angewandte Chemie (International ed. in English) · 2021Article
- Tuneable Control of Organocatalytic Activity through Host-Guest Chemistry.Angewandte Chemie (International ed. in English) · 2021Article
- Fluorescent Molecular Cages with Sucrose and Cyclotriveratrylene Units for the Selective Recognition of Choline and Acetylcholine.The Journal of organic chemistry · 2021Article
- On the use of catalysis to bias reaction pathways in out-of-equilibrium systems.Chemical science · 2021Article
- A Bioorthogonal Small Molecule Selective Polymeric "Clickase".Journal of the American Chemical Society · 2020Article
- Conditional Copper-Catalyzed Azide-Alkyne Cycloaddition by Catalyst Encapsulation.Angewandte Chemie (International ed. in English) · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
Supramolecular encapsulation is known to alter chemical properties of guest molecules. We have applied this strategy of molecular encapsulation to temporally control the catalytic activity of a stable copper(I)-carbene catalyst. Encapsulation of the copper(I)-carbene catalyst by the supramolecular host cucurbit[7]uril (CB[7]) resulted in the complete inactivation of a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The addition of a chemical signal achieved the near instantaneous activation of the catalyst, by releasing the catalyst from the inhibited CB[7] catalyst complex. To broaden the scope of our on-demand CuAAC reaction, we demonstrated the protein labeling of vinculin with the copper(I)-carbene catalyst, to inhibit its activity by encapsulation with CB[7] and to initiate labeling at any moment by adding a specific signal molecule. Ultimately, this strategy allows for temporal control over copper-catalyzed click chemistry, on small molecules as well as protein targets.
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