ArticleNephrology (Carlton, Vic.)2020
Aetiology of chronic kidney disease and risk factors for disease progression in Chinese subjects: A single-centre retrospective study in Beijing.
Article in Nephrology (Carlton, Vic.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Clinical effect ofFrontiers in pharmacology · 2023Pooled it
- Spectrum and clinical profile of glomerular diseases in a Nepalese cohort, a tertiary care center study: focus on comparing IgA nephropathy with other primary glomerulonephritis.BMC nephrology · 2025Article
- Inhibitory effects of herbal monomers on ferroptosis in renal fibrosis: a review and mechanistic study.Frontiers in pharmacology · 2025Review
- Prevalence and associations of chronic kidney disease among antiretroviral therapy-naïve persons living with HIV in Lagos, Nigeria.BMC nephrology · 2024Article
- Risk factors for preeclampsia in patients with chronic kidney disease primarily focused on stage 1 CKD. Are referred and registered patients alike?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Cumulative blood pressure load and hypertensive nephropathy in Han Chinese hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- The Prevalence, Progress and Risk Factor Control of Chronic Kidney Disease in Chinese Adults With Type 2 Diabetes Mellitus in Primary Care.Frontiers in endocrinology · 2022Article
- Risk Factors for Progression of CKD with and without Diabetes.Journal of diabetes research · 2022Article
- Article
- Aetiology of chronic kidney disease and risk factors for disease progression in Chinese subjects: A single-centre retrospective study in Beijing.Nephrology (Carlton, Vic.) · 2020Article
- Dietary Habit and Other Risk Factors of Chronic Kidney Disease Among Patients Attending Dessie Referral Hospital, Northeast Ethiopia.International journal of nephrology and renovascular disease · 2020Article
- Blood Pressure Control and its Determinants among Patients with Chronic Kidney Disease in a Nigerian Tertiary Hospital: A Cross-Sectional Study.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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Authors and funding
6 authors at 3 institutions in 6 countries.
Funding
Abstract
aimTo assess the aetiological factors of chronic kidney disease (CKD) and factors associated with disease progression.
methodsSingle-centre retrospective study evaluating thorough electronic medical records of patients diagnosed with CKD at Peking University People's Hospital (April 2010-April 2015). The objectives were to identify the aetiological factors of CKD in Chinese patients and risk factors associated with CKD progression.
resultsOf 15 425 CKD patients, 12 380 had aetiology recorded. The leading aetiologies associated with CKD were chronic glomerulonephritis (CGN; 36.8%), hypertensive nephropathy (HTN; 28.5%) and diabetic nephropathy (DN; 27.1%). CGN was most common in patients with early stage disease (stages 1-2); DN and HTN were common in advanced-stages (stages 3-4). In a longitudinal subcohort of 2923 patients with ≥6-month follow-up, 19.6% experienced CKD progression. Patients with CKD progression were significantly older in age and had a greater number of comorbidities and laboratory anomalies, and were more likely to have DN (40.5%) and CGN (40.5%) than HTN (5.5%) at baseline than patients without progression. In a multivariate analysis, factors associated with disease progression included macro- and micro-albuminuria, anaemia, hyperkalaemia, hyperphosphataemia, metabolic acidosis, CKD stage 4 and type 2 diabetes mellitus (T2DM).
conclusionThis study identified CGN, DN and HTN as the leading aetiological factors for CKD in Chinese patients. DN was a strong predictor of faster disease progression, with albuminuria (a complication of T2DM) associated with highest risk for disease progression.
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