Evidence map›Paper›PMID 32180219›Full record

ArticleBritish journal of haematology2020

The combination of ibrutinib and rituximab demonstrates activity in first-line follicular lymphoma.

Nathan H Fowler, Loretta Nastoupil, Sven De Vos, Mark Knapp, Ian W Flinn, Robert Chen, Ranjana H Advani, Sumeet Bhatia, Peter Martin, Raul Mena and 8 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in British journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07126678 (Prospective Exploratory Study of Fixed-Duration Zanubrutinib, Bendamustine, and Obinutuzumab), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07126678 narecruitingnot on this mapstarted 2025, after this paper: background citation

Prospective Exploratory Study of Fixed-Duration Zanubrutinib, Bendamustine, and Obinutuzumab (ZBG) in Treatment-Naïve Advanced Stage Follicular Lymphoma

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2025 to 2028Enrolled15ConditionsFollicular Lymphoma, Treatment NaiveArmszanubrutinib, bendamustine, and obinutuzumab
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Advancements in the Management of Follicular Lymphoma: A Comprehensive ReviewTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Targeted Treatment of Follicular Lymphoma.Journal of personalized medicine · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

Nathan H FowlerUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Loretta NastoupilUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sven De VosDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Mark KnappZangmeister Cancer Center, Columbus, OH, USA.
Ian W FlinnSarah Cannon Research Institute, Nashville, TN, USA.ORCID 0000-0001-6724-290X
Robert ChenCity of Hope, Duarte, CA, USA.
Ranjana H AdvaniStanford University School of Medicine, Stanford, CA, USA.
Sumeet BhatiaCommunity Health Network, Indianapolis, IN, USA.
Peter MartinWeill Cornell Medical College, New York, NY, USA.ORCID 0000-0001-7813-1551
Raul MenaProvidence St. Joseph Medical Center, Burbank, CA, USA.
Richard Eric DavisUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sattva S NeelapuUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Karl EckertPharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Jerry PingPharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Melannie CoPharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Darrin M BeauprePharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
Jutta K NeuenburgPharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA.
M Lia PalombaMemorial Sloan Kettering Cancer Center, New York, NY, USA.
AbbVie (United States) · USThe University of Texas MD Anderson Cancer Center · USCity of Hope · USCommunity Health Network · USCornell University · USMark H. Zangmeister Cancer Center · USMemorial Sloan Kettering Cancer Center · USProvidence Saint Joseph Medical Center · USSarah Cannon · USStanford University · USUniversity of California, Los Angeles · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748Pharmacyclics, LLC, an AbbVie Company Not applicable
6 · The paper itself

Abstract

This phase 2 study evaluated the activity and safety of ibrutinib, a Bruton's tyrosine kinase inhibitor, plus rituximab in adults with previously untreated follicular lymphoma. Patients received once-daily ibrutinib 560 mg continuously plus once-weekly rituximab 375 mg/m

Indexed as

AdenineAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansLymphoma, FollicularMaleMiddle AgedPiperidinesRituximabAdenineibrutinibPiperidinesRituximabfollicular lymphomaibrutinibrituximab

Identifiers

PMID32180219
PMCPMC7317728
OpenAlexW3012031439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.