Evidence map›Paper›PMID 32180132›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2020

Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14

Tsuneya Ikezu, Lacin Koro, Benjamin Wolozin, Francis A Farraye, Audrey J Strongosky, Zbigniew K Wszolek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.Movement disorders : official journal of the Movement Disorder Society · 2022
    Pooled it
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  18. Genetic and Environmental Factors Influence the Pleomorphy ofInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tsuneya IkezuDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA. tikezu@bu.edu.ORCID 0000-0002-3979-8596
Lacin KoroDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Benjamin WolozinDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
Francis A FarrayeSection of Gatroenterology, Inflammatory Bowel Disease Center, Boston University School of Medicine, Boston, MA, 02118, USA.
Audrey J StrongoskyDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Boston University · USMayo Clinic in Florida · US

Funding

Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteinsRF1AG056318 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LI, HU, WOLOZIN, BENJAMIN L · 2018 to 2020
$4.4M
RNA binding proteins as novel targets in Alzheimer's diseaseR01AG050471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WOLOZIN, BENJAMIN L · 2015 to 2019
$2.9M
QUANTSTUDIO 12K FLEX OPEN ARRAY REAL-TIME PCR SYSTEMS10OD023663 · OD · BOSTON MEDICAL CENTER · PI DENG, LINGYI L · 2017 to 2017
$186k
NIA NIH HHS R01 AG050471NIA NIH HHS RF1 AG056318NIH HHS S10 OD023663
6 · The paper itself

Abstract

The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson's disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn's disease (CD). LRRK2 is expressed in human CD14

Indexed as

AdultCrohn DiseaseFemaleHumansImmunity, InnateInterferon-gammaLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lipopolysaccharide ReceptorsMaleMiddle AgedMonocytesMutationParkinson DiseaseCD14 protein, humanInterferon-gammaLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lipopolysaccharide ReceptorsLRRK2 protein, humanCrohn’s diseaseLRRK2MonocytesParkinson’s diseaseSingle nucleotide polymorphismType II interferon

Identifiers

PMID32180132
PMCPMC7718203
OpenAlexW3011379368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.