ArticleInternational journal of colorectal disease2020
Perineural invasion is associated with poor prognosis of colorectal cancer: a retrospective cohort study.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Prognostic and clinicopathological value of perineural invasion in colorectal cancer: a meta-analysis.Frontiers in oncology · 2026Pooled it
- Integrins as key regulators in tumor perineural invasion: mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Unraveling the nexus in the neuro-neoplastic progression of colorectal cancer: Potential role of β2-adrenergic receptor (β2-AR).Journal of advanced research · 2026Review
- Neuro-immune interactions in cancer: mechanisms and therapeutic prospects.Frontiers in immunology · 2026Review
- Competing risk and random survival forest models for predicting survival in post-resection elderly stage I-III colorectal cancer patients.Scientific reports · 2025Article
- A comprehensive study on the radiomic score derived from perineural invasion in gastric cancer and its correlation with the overall survival of patients.La Radiologia medica · 2025Article
- Development of a nomogram predicting perineural invasion risk and assessment of the prognostic value of perineural invasion in colon cancer: a population study based on the Surveillance, Epidemiology, and End Results database.Translational cancer research · 2025Article
- Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth.Journal of translational medicine · 2025Article
- Single-cell and bulk RNA-sequencing reveal PRRX2-driven cancer-associated fibroblast-mediated perineural invasion for predicting the immunotherapy outcome in colorectal cancer.Frontiers in cell and developmental biology · 2025Article
- Predicting lung metastasis after radical colorectal cancer surgery: a two center retrospective cohort study and nomogram development.Frontiers in oncology · 2025Article
- Brachial plexopathy due to perineural tumor spread: a retrospective single-center experience of clinical manifestations, diagnosis, treatments, and outcomes.Acta neurochirurgica · 2024Article
- Neural Circuitries between the Brain and Peripheral Solid Tumors.Cancer research · 2024Review
- Spectral CT in the evaluation of perineural invasion status in rectal cancer.Japanese journal of radiology · 2024Article
- Article
- Combining perineural invasion with staging improve the prognostic accuracy in colorectal cancer: a retrospective cohort study.BMC cancer · 2023Article
- Perineural invasion affects prognosis of patients undergoing colorectal cancer surgery: a propensity score matching analysis.BMC cancer · 2023Article
- Novel applications of histopathological markers to distinguish prognostic subgroups in colorectal adenocarcinoma.Annals of medicine · 2023Article
- Computed tomography-based radiomics nomogram for the preoperative prediction of perineural invasion in colorectal cancer: a multicentre study.Abdominal radiology (New York) · 2022Article
- Perineural invasion is a prognostic factor in stage II colorectal cancer but not a treatment indicator for traditional chemotherapy: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- Schwann cells promote the migration and invasion of colorectal cancer cellsFrontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposePerineural invasion (PNI) is associated with poor prognosis in a variety of cancers. Our aim was to determine the clinicopathological factors associated with PNI in colorectal cancer (CRC) and its impact on patient survival. MATERIAL AND
methodsThe clinical data of 1412 patients diagnosed with CRC from July 2013 to July 2016 were retrospectively collected. PNI was determined based on hematoxylin-eosin staining. The relationships of PNI with various clinicopathological factors and prognosis were analyzed.
resultsThe incidence of PNI in the entire cohort was 21.5%. PNI was significantly more common in patients with lower tumor differentiation, higher tumor stage, vascular invasion, TNM stage, tumor diameter, MMR/KRAS/NRAS/BRAF mutation, and more positive lymph nodes. Logistic regression analysis showed that T stage, vascular invasion, tumor diameter, and MMR were the main influencing factors of PNI. Cox regression analysis showed that poor tumor differentiation, N stage, TNM stage, PNI, and BRAF status were independent prognostic factors for OS. The OS, CSS, and PFS rate of the PNI (-) group was higher than that of the PNI (+) group, and the difference was statistically significant (P < 0.001).
conclusionPNI in patients with colorectal cancer is significantly associated with T stage, TNM stage, vessel invasion, tumor diameter, MMR status, and BRAF mutation. PNI status is an independent prognostic factor for CRC. Assessing the postoperative PNI status may help predict prognosis and determine further treatment options for these patients.
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