Evidence map›Paper›PMID 32179982›Full record

ArticleVirchows Archiv : an international journal of pathology2020

The effect of the peritoneal tumor microenvironment on invasion of peritoneal metastases of high-grade serous ovarian cancer and the impact of NEOADJUVANT chemotherapy.

J O A M van Baal, C A R Lok, E S Jordanova, H Horlings, W J van Driel, F C Amant, K K Van de Vijver

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

J O A M van BaalDepartment of Gynecology, Center for Gynecologic Oncology Amsterdam, P.O. Box 90203, Amsterdam, 1006, BE, The Netherlands. j.v.baal@nki.nl.
C A R LokDepartment of Gynecology, Center for Gynecologic Oncology Amsterdam, P.O. Box 90203, Amsterdam, 1006, BE, The Netherlands.
E S JordanovaDepartment of Gynecology, Center for Gynecologic Oncology Amsterdam, P.O. Box 90203, Amsterdam, 1006, BE, The Netherlands.
H HorlingsDivision of Diagnostic Oncology & Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
W J van DrielDepartment of Gynecology, Center for Gynecologic Oncology Amsterdam, P.O. Box 90203, Amsterdam, 1006, BE, The Netherlands.
F C AmantDepartment of Gynecology, Center for Gynecologic Oncology Amsterdam, P.O. Box 90203, Amsterdam, 1006, BE, The Netherlands.
K K Van de VijverDivision of Diagnostic Oncology & Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Ghent University Hospital · BEThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal metastases of high-grade serous ovarian cancer (HGSOC) are small-sized deposits with superficial growth toward the peritoneal cavity. It is unknown whether integrity of the peritoneal elastic lamina (PEL) correlates with the peritoneal tumor microenvironment (pTME) and whether neoadjuvant chemotherapy (NACT) affects the pTME. We explored integrity of PEL, composition of pTME, effects of NACT, and the prognostic implications in patients with extensive peritoneal metastases of HGSOC. Peritoneal samples (n = 69) were collected during cytoreductive surgery between 2003 and 2016. Clinical data were collected from medical charts. Integrity of PEL was evaluated with elastic stains. T cell (CD3, CD8) and M2-macrophage markers (CD163) were scored using algorithms created in definiens tissue studio. Patients with a disrupted PEL (n = 39; 57%), more often had residual disease after surgery (p = 0.050), compared to intact PEL. An intact PEL was associated with increased intraepithelial (ie) CD8+ cells (p = 0.032), but was not correlated with improved survival. After NACT, increased ieCD3+ cells were shown, compared to no-NACT (p = 0.044). Abundance of total CD3+ and CD8+ cells were associated with PFS (multivariate HR 0.40; 95%CI 0.23-0.69 and HR 0.49; 95%CI 0.29-0.83) and OS (HR 0.33; 95%CI 0.18-0.62 and HR 0.36; 95%CI 0.20-0.64). M2-macrophage infiltration was not correlated with survival. NACT increases abundance of ieCD3+ cells in peritoneal metastases of HGSOC. Increase of CD3+ and CD8+ cells is associated with improved PFS and OS. This suggests that CD3+ and CD8+ cells may function as prognostic biomarkers. Their role as predictive biomarker for chemotherapy or immunotherapy response in HGSOC warrants further research.

Indexed as

Neoadjuvant TherapyTumor MicroenvironmentAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCD3 ComplexCD8-Positive T-LymphocytesCytoreduction Surgical ProceduresFemaleHumansLymphocytes, Tumor-InfiltratingMacrophagesMiddle AgedNeoplasm GradingNeoplasm InvasivenessAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCD3 ComplexReceptors, Cell SurfaceHigh-grade serous ovarian cancerPeritoneal elastic laminaPeritoneal metastasesPeritoneal tumor microenvironmentTumor-infiltrating lymphocytes

Identifiers

PMID32179982
OpenAlexW3010657767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.