ArticleApplied microbiology and biotechnology2020
Peroxidase activities of gold nanowires synthesized by TMV as template and their application in detection of cancer cells.
Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 21 citations in OpenAlex.
- Emerging trends in the fabrication and applications of plant virus-gold nanoparticle hybrids: A comprehensive review.Materials today. Bio · 2025Review
- Regulating electronic states of porous branched core-shell Pd@PtCo nanozyme by Co-doping for boosting colorimetric analytical performance of ascorbic acid and hydrogen peroxide.Mikrochimica acta · 2025Article
- Propelling gold nanozymes: catalytic activity and biosensing applications.Analytical and bioanalytical chemistry · 2024Review
- Electroless Deposition of Noble Metals on Rod-Shape Plant Viruses in Various Aqueous Metal Precursor Solutions.ACS omega · 2024Article
- Mesoporous silica stabilized Cu-Fe bimetallic nanozymes for total antioxidant capacity assay of fruit foods.Applied microbiology and biotechnology · 2023Article
- Fabrication and Molecular Modeling of Navette-Shaped Fullerene Nanorods Using Tobacco Mosaic Virus as a Nanotemplate.Molecular biotechnology · 2022Article
- Nanozymes-Hitting the Biosensing "Target".Sensors (Basel, Switzerland) · 2021Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
A sensing methodology that combines Au, tobacco mosaic virus (TMV), and folic acid for selective, sensitive, and colorimetric detection of tumor cells based on the peroxidase-like activity was reported in this study. Gold nanowires with a high aspect ratio were synthesized using TMV as a template. Au@TMV nanowire (AT) complex was obtained with diameter of 4 nm and length between 200 and 300 nm. In addition, since TMV was biocompatible and had many amino and carboxyl groups on its surface, AT was conjugated by folate to form a folic acid (FA)-conjugated AT composite (ATF) and tested by FTIR measurements. Furthermore, the peroxidase-like properties were studied and the optimal conditions for mimic enzyme activity were optimized. Finally, HeLa and other tumor cells expressed excessive receptors of folate on the surface, which can specifically bind to folic acid. As the specific binding of ATF with HeLa cells, the peroxidase properties of ATF were used for detection of cancer cells (Scheme 1). The cancer cells were detected not only qualitatively but also quantitatively. In this study, as low as 2000 cancer cells/mL could be detected using the current method.
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