Evidence map›Paper›PMID 32179829›Full record

ArticleScientific reports2020

Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair.

Mustafa Rashid, Jayesh Dudhia, Stephanie G Dakin, Sarah J B Snelling, Roberta De Godoy, Pierre-Alexis Mouthuy, Roger K W Smith, Mark Morrey, Andrew J Carr

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Effect of curcumin-loaded polycaprolactone scaffold on Achilles tendon repair in rats.Veterinary research forum : an international quarterly journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mustafa RashidNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Jayesh DudhiaDepartment of Clinical Sciences and Services, Royal Veterinary College, University of London, North Mymms, UK.ORCID http://orcid.org/0000-0002-2503-697X
Stephanie G DakinNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Sarah J B SnellingNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Roberta De GodoyDepartment of Clinical Sciences and Services, Royal Veterinary College, University of London, North Mymms, UK.ORCID http://orcid.org/0000-0003-0037-5286
Pierre-Alexis MouthuyNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Roger K W SmithDepartment of Clinical Sciences and Services, Royal Veterinary College, University of London, North Mymms, UK.
Mark MorreyNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Andrew J CarrNuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK. andrew.carr@ndorms.ox.ac.uk.
Nuffield Orthopaedic Centre · GBUniversity of London · GBMayo Clinic · US

Funding

Medical Research Council MC_PC_14103Medical Research Council MR/J006815/1Medical Research Council MR/R015651/1
6 · The paper itself

Abstract

We investigated endogenous tissue response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch intended for tendon repair. A sheep tendon injury model characterised by a natural history of consistent failure of healing was chosen to assess the biological potential of woven and aligned electrospun fibres to induce a reparative response. Patches were implanted into 8 female adult English Mule sheep. Significant infiltration of tendon fibroblasts was observed within the electrospun component of the patch but not within the woven component. The cellular infiltrate into the electrospun fibres was accompanied by an extensive network of new blood vessel formation. Tendon fibroblasts were the most abundant scaffold-populating cell type. CD45

Indexed as

PolydioxanonePolyestersTissue ScaffoldsAnimalsDisease Models, AnimalFemaleFibroblastsPlastic Surgery ProceduresSheepTendon InjuriesTendonsWound HealingpolycaprolactonePolydioxanonePolyesters

Identifiers

PMID32179829
PMCPMC7076042
OpenAlexW3012259619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.