Evidence map›Paper›PMID 32179785›Full record

ArticleScientific reports2020

Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages.

Pavlína Šimečková, František Hubatka, Jan Kotouček, Pavlína Turánek Knötigová, Josef Mašek, Josef Slavík, Ondrej Kováč, Jiří Neča, Pavel Kulich, Dominik Hrebík and 9 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Contrast Agents for Enhanced Bioimaging: A Comprehensive Review.Chembiochem : a European journal of chemical biology · 2026
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  18. Histological findings for the absorption of small and large liposomes - the basis of future drug delivery and contrast media systems.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Pavlína ŠimečkováVeterinary Research Institute, Brno, Czech Republic.
František HubatkaVeterinary Research Institute, Brno, Czech Republic.
Jan KotoučekVeterinary Research Institute, Brno, Czech Republic.
Pavlína Turánek KnötigováVeterinary Research Institute, Brno, Czech Republic.
Josef MašekVeterinary Research Institute, Brno, Czech Republic.
Josef SlavíkVeterinary Research Institute, Brno, Czech Republic.
Ondrej KováčVeterinary Research Institute, Brno, Czech Republic.
Jiří NečaVeterinary Research Institute, Brno, Czech Republic.
Pavel KulichVeterinary Research Institute, Brno, Czech Republic.
Dominik HrebíkCentral European Institute of Technology CEITEC, Structural Virology, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-4568-0196
Jana StráskáRegional Centre of Advanced Technologies and Materials, Palacký University, Olomouc, Czech Republic.
Kateřina PěnčíkováVeterinary Research Institute, Brno, Czech Republic.
Jiřina ProcházkováVeterinary Research Institute, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-2738-8546
Pavel DivišFaculty of Chemistry, Technical University, Brno, Czech Republic.
Stuart MacaulayMalvern Instruments, Great Malvern, UK.
Robert MikulíkInternational Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic.
Milan RaškaVeterinary Research Institute, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-8572-7246
Miroslav MachalaVeterinary Research Institute, Brno, Czech Republic. machala@vri.cz.
Jaroslav TuránekVeterinary Research Institute, Brno, Czech Republic. turanek@vri.cz.
Veterinary Research Institute · CZCentral European Institute of Technology · CZCzech Technical University in Prague · CZMalvern Community Hospital · GBMasaryk University · CZRegional Centre of Advanced Technologies and Materials · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and treatment of various pathological states including stroke. In this study, we evaluated nanosafety of Gd-lip containing PE-DTPA chelating Gd

Indexed as

Contrast MediaDrug CarriersGadolinium DTPALiposomesMagnetic Resonance ImagingPhosphatidylethanolaminesCells, CulturedFibrinolytic AgentsHepatocytesHumansInflammasomesMacrophagesNanoparticlesNLR Family, Pyrin Domain-Containing 3 ProteinContrast MediaDrug CarriersFibrinolytic AgentsGadolinium DTPAgadolinium phosphatidylethanolamine-DTPAInflammasomesLiposomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPhosphatidylethanolamines

Identifiers

PMID32179785
PMCPMC7075985
OpenAlexW3012351568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.