ArticleNature communications2020
Dense active matter model of motion patterns in confluent cell monolayers.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Controlling tissue size by active fracture.Physical review. E · 2026Article
- Topological signatures of collective dynamics and turbulent-like energy cascades in apolar active granular matter.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Self-propulsive active nematics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- A multicellular star-shaped actin network underpins epithelial organization and connectivity.Nature communications · 2025Article
- Enhanced long wavelength Mermin-Wagner-Hohenberg fluctuations in active crystals and glasses.Nature communications · 2025Article
- Flocking and giant fluctuations in epithelial active solids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics.Nature communications · 2024Article
- Short-range correlation of stress chains near solid-to-liquid transition in active monolayers.Journal of the Royal Society, Interface · 2024Article
- Machine learning topological defects in confluent tissues.Biophysical reports · 2024Article
- Dynamical heterogeneity in active glasses is inherently different from its equilibrium behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Stress anisotropy in confined populations of growing rods.Journal of the Royal Society, Interface · 2022Article
- Hydrodynamic effects on the liquid-hexatic transition of active colloids.The European physical journal. E, Soft matter · 2022Article
- Linear viscoelastic properties of the vertex model for epithelial tissues.PLoS computational biology · 2022Article
- Learning the rules of collective cell migration using deep attention networks.PLoS computational biology · 2022Article
- Cell-cell interactions and fluctuations in the direction of motility promote directed migration of osteoblasts in direct current electrotaxis.Frontiers in bioengineering and biotechnology · 2022Article
- Shear-induced orientational ordering in an active glass former.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Epithelial cell monolayers show remarkable displacement and velocity correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids and active nematics. We show that many observed features can be described within the framework of dense active matter, and argue that persistent uncoordinated cell motility coupled to the collective elastic modes of the cell sheet is sufficient to produce swirl-like correlations. We obtain this result using both continuum active linear elasticity and a normal modes formalism, and validate analytical predictions with numerical simulations of two agent-based cell models, soft elastic particles and the self-propelled Voronoi model together with in-vitro experiments of confluent corneal epithelial cell sheets. Simulations and normal mode analysis perfectly match when tissue-level reorganisation occurs on times longer than the persistence time of cell motility. Our analytical model quantitatively matches measured velocity correlation functions over more than a decade with a single fitting parameter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.