ArticleNature communications2020
Chiral twisting in a bacterial cytoskeletal polymer affects filament size and orientation.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Alanine-scanning mutagenesis library of MreB reveals distinct roles for regulating cell shape and viability.PLoS genetics · 2026Article
- Cooperative and divergent properties of bacterial actin isoforms inBiophysics and physicobiology · 2026Article
- Sensing the shape of a surface by tightly surface-bound filaments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- MreB filaments in the elongasome modulate E. coli membrane curvature.Biophysical journal · 2025Article
- Article
- Complex state transitions of the bacterial cell division protein FtsZ.Molecular biology of the cell · 2024Article
- Self-organization of mortal filaments and its role in bacterial division ring formation.Nature physics · 2024Article
- Article
- Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96.Mikrochimica acta · 2023Article
- Curved crease origami and topological singularities at a cellular scale enable hyper-extensibility ofbioRxiv : the preprint server for biology · 2023Article
- Feedback linking cell envelope stiffness, curvature, and synthesis enables robust rod-shaped bacterial growth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Molecular Dynamics Simulations of Curved Lipid Membranes.International journal of molecular sciences · 2022Review
- Filament organization of the bacterial actin MreB is dependent on the nucleotide state.The Journal of cell biology · 2022Article
- Bending-torsional elasticity and energetics of the plus-end microtubule tip.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Multiple conserved states characterize the twist landscape of the bacterial actin homolog MreB.Computational and structural biotechnology journal · 2022Article
- Article
- Review
- Control of septum thickness by the curvature of SepF polymers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- AimB Is a Small Protein Regulator of Cell Size and MreB Assembly.Biophysical journal · 2020Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
In many rod-shaped bacteria, the actin homolog MreB directs cell-wall insertion and maintains cell shape, but it remains unclear how structural changes to MreB affect its organization in vivo. Here, we perform molecular dynamics simulations for Caulobacter crescentus MreB to extract mechanical parameters for inputs into a coarse-grained biophysical polymer model that successfully predicts MreB filament properties in vivo. Our analyses indicate that MreB double protofilaments can exhibit left-handed twisting that is dependent on the bound nucleotide and membrane binding; the degree of twisting correlates with the length and orientation of MreB filaments observed in vitro and in vivo. Our molecular dynamics simulations also suggest that membrane binding of MreB double protofilaments induces a stable membrane curvature of similar magnitude to that observed in vivo. Thus, our multiscale modeling correlates cytoskeletal filament size with conformational changes inferred from molecular dynamics simulations, providing a paradigm for connecting protein filament structure and mechanics to cellular organization and function.
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