ArticleProceedings of the National Academy of Sciences of the United States of America2020
Macroscopic information-based taste representations in insular cortex are shaped by stimulus concentration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- The Isle of Craig: Neuroanatomical and Functional Evidence for a Role of the Insular Cortex in Subjective Feelings.Current topics in behavioral neurosciences · 2025Review
- Seeing and extrapolating motion trajectories share common informative activation patterns in primary visual cortex.Human brain mapping · 2023Article
- Encoding Taste: From Receptors to Perception.Handbook of experimental pharmacology · 2022Article
- Effective Connectivity in the Human Brain for Sour Taste, Retronasal Smell, and Combined Flavour.Foods (Basel, Switzerland) · 2021Article
- Against gustotopic representation in the human brain: There is no Cartesian Restaurant.Current opinion in physiology · 2021Article
- Glucagon-Like Peptide 1 and Taste Perception: From Molecular Mechanisms to Potential Clinical Implications.International journal of molecular sciences · 2021Review
- Viewing images of foods evokes taste quality-specific activity in gustatory insular cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- Hedonicity in functional motor disorders: a chemosensory study assessing taste.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taste processing is an essential ability in all animals signaling potential harm or benefit of ingestive behavior. However, current evidence for cortical taste representations remains contradictory. To address this issue, high-resolution functional MRI (fMRI) and multivariate pattern analysis were used to characterize taste-related informational content in human insular cortex, which contains primary gustatory cortex. Human participants judged pleasantness and intensity of low- and high-concentration tastes (salty, sweet, sour, and bitter) in two fMRI experiments on two different days to test for task- and concentration-invariant taste representations. We observed patterns of fMRI activity within insular cortex narrowly tuned to specific tastants consistently across tasks in all participants. Fewer patterns responded to more than one taste category. Importantly, changes in taste concentration altered the spatial layout of putative taste-specific patterns with distinct, almost nonoverlapping patterns for each taste category at different concentration levels. Together, our results point at macroscopic representations in human insular cortex as a complex function of taste category and concentration rather than representations based solely on taste identity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.