ArticleProceedings of the National Academy of Sciences of the United States of America2020
US life expectancy stalls due to cardiovascular disease, not drug deaths.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06263452 (Beta-Blocker Influences on Inflammatory and Neural Responses to Stress), which is not on this map. Cited by 112 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
Who cites it
112 citing papers in PubMed.
- Trial
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- Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach.Chronic diseases and translational medicine · 2026Article
- Psychological Resilience to Trauma and Risk of Metabolic Syndrome in Women.Biopsychosocial science and medicine · 2026Article
- Risk stacking in peripheral artery disease (PAD): Integrating genetics, cardiometabolic disease and social determinants of health to explain worsening PAD outcomes.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Sicker at all ages? Two decades of changing disease histories and mortality in the United States.International journal of epidemiology · 2026Article
- Cardiovascular Risk Factor Prevalence and Control by Education Strata in Older Adults in 3 Countries.JAMA network open · 2026Article
- Causes of Excess Deaths in the US Compared With Other High-Income Countries.JAMA network open · 2026Article
- LDL-C combined with Chinese visceral adiposity index as a risk stratification tool for cardiometabolic multimorbidity in middle-aged and older Chinese adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- A Double Decomposition of Standard Deviation Below the Modal Age at Death and the Role of Causes of Death.European journal of population = Revue europeenne de demographie · 2026Article
- Insights into US life expectancy stagnation from birth cohort mortality dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Slowdown in mortality improvements and trends in lifespan inequality across high-income countries: the role of changing causes of death, 2010-2021.European journal of public health · 2026Article
- Spatial Social Polarization and Cardiometabolic Disease Prevalence and Incidence: What Is the Role of the Neighborhood Environment?Journal of health and social behavior · 2026Article
- Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia.BMC medicine · 2026Article
- Potential and challenges for sustainable progress in human longevity.Nature communications · 2026Article
- Can alcohol use explain the increase in educational inequalities in all-cause mortality after 2010 in the USA? A three-way interaction analysis.Addiction (Abingdon, England) · 2026Article
- Age-specific trends in limitations of daily activities in American adults aged 50-84 by race and ethnicity, 2000-2018.PloS one · 2026Article
- Gaps in Population Life Course Phenotype Trajectories Underlying Major Noncommunicable Diseases: A Scoping Review.International journal of population data science · 2026Article
- Stagnating declines in cardiovascular disease mortality in the United States expanded the black-white life expectancy gap.Preventive medicine · 2026Article
- National Life Expectancy Lags Behind Benchmark Progress and the Role of Smoking: An International Comparison.European journal of population = Revue europeenne de demographie · 2025Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
After decades of robust growth, the rise in US life expectancy stalled after 2010. Explanations for the stall have focused on rising drug-related deaths. Here we show that a stagnating decline in cardiovascular disease (CVD) mortality was the main culprit, outpacing and overshadowing the effects of all other causes of death. The CVD stagnation held back the increase of US life expectancy at age 25 y by 1.14 y in women and men, between 2010 and 2017. Rising drug-related deaths had a much smaller effect: 0.1 y in women and 0.4 y in men. Comparisons with other high-income countries reveal that the US CVD stagnation is unusually strong, contributing to a stark mortality divergence between the US and peer nations. Without the aid of CVD mortality declines, future US life expectancy gains must come from other causes-a monumental task given the enormity of earlier declines in CVD death rates. Reversal of the drug overdose epidemic will be beneficial, but insufficient for achieving pre-2010 pace of life expectancy growth.
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