ArticlePediatrics2020
Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected Pneumonia.
Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Testing and Treatment Thresholds for Pediatric Pneumonia in the Emergency Department.Hospital pediatrics · 2024Article
- Outpatient Antibiotic Use and Treatment Failure Among Children With Pneumonia.JAMA network open · 2024Article
- Outcomes of antibiotic treatment for respiratory infections in children an observational study in primary care.Scandinavian journal of primary health care · 2024Observational
- Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment.Clinical and experimental pediatrics · 2024Article
- Essential Concepts for Reducing Bias in Observational Studies.Hospital pediatrics · 2023Observational
- Article
- The dilemma of improving rational antibiotic use in pediatric community-acquired pneumonia.Frontiers in pediatrics · 2023Review
- Antibiotic use and outcomes among children hospitalized with suspected pneumonia.Journal of hospital medicine · 2022Article
- Article
- Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study.Journal of ultrasound · 2022Article
- Determinants of antibiotic prescriptions in a large cohort of children discharged from a pediatric emergency department.European journal of pediatrics · 2022Observational
- Antibiotic Use and Outcomes in Young Children Hospitalized With Uncomplicated Community-Acquired Pneumonia.Open forum infectious diseases · 2022Article
- Methodological progress note: A clinician's guide to propensity scores.Journal of hospital medicine · 2022Article
- Implementation of lung ultrasound in low- to middle-income countries: a new challenge global health?European journal of pediatrics · 2022Review
- Could It Be Pneumonia? Lung Ultrasound in Children With Low Clinical Suspicion for Pneumonia.Pediatric quality & safetyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
objectivesAntibiotic therapy is often prescribed for suspected community-acquired pneumonia (CAP) in children despite a lack of knowledge of causative pathogen. Our objective in this study was to investigate the association between antibiotic prescription and treatment failure in children with suspected CAP who are discharged from the hospital emergency department (ED).
methodsWe performed a prospective cohort study of children (ages 3 months-18 years) who were discharged from the ED with suspected CAP. The primary exposure was antibiotic receipt or prescription. The primary outcome was treatment failure (ie, hospitalization after being discharged from the ED, return visit with antibiotic initiation or change, or antibiotic change within 7-15 days from the ED visit). The secondary outcomes included parent-reported quality-of-life measures. Propensity score matching was used to limit potential bias attributable to treatment selection between children who did and did not receive an antibiotic prescription.
resultsOf 337 eligible children, 294 were matched on the basis of propensity score. There was no statistical difference in treatment failure between children who received antibiotics and those who did not (odds ratio 1.0; 95% confidence interval 0.45-2.2). There was no difference in the proportion of children with return visits with hospitalization (3.4% with antibiotics versus 3.4% without), initiation and/or change of antibiotics (4.8% vs 6.1%), or parent-reported quality-of-life measures.
conclusionsAmong children with suspected CAP, the outcomes were not statistically different between those who did and did not receive an antibiotic prescription.
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Registered trials
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