ArticleLearning & memory (Cold Spring Harbor, N.Y.)2020
Odor modulates the temporal dynamics of fear memory consolidation.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Mitochondrial CaNature metabolism · 2026Article
- Basolateral Amygdala Astrocytes Are Engaged by the Acquisition and Expression of a Contextual Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear.Nature communications · 2022Article
- Social reactivation of fear engrams enhances memory recall.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams.International journal of molecular sciences · 2021Review
- Developmental emergence of persistent memory for contextual and auditory fear in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Systems consolidation (SC) theory proposes that recent, contextually rich memories are stored in the hippocampus (HPC). As these memories become remote, they are believed to rely more heavily on cortical structures within the prefrontal cortex (PFC), where they lose much of their contextual detail and become schematized. Odor is a particularly evocative cue for intense remote memory recall and despite these memories being remote, they are highly contextual. In instances such as posttraumatic stress disorder (PTSD), intense remote memory recall can occur years after trauma, which seemingly contradicts SC. We hypothesized that odor may shift the organization of salient or fearful memories such that when paired with an odor at the time of encoding, they are delayed in the de-contextualization process that occurs across time, and retrieval may still rely on the HPC, where memories are imbued with contextually rich information, even at remote time points. We investigated this by tagging odor- and non-odor-associated fear memories in male c57BL/6 mice and assessed recall and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.