Evidence map›Paper›PMID 32179646›Full record

ArticleThe Journal of biological chemistry2020

Structure-based discovery of a small-molecule inhibitor of methicillin-resistant

Jie Liu, Lina Kozhaya, Victor J Torres, Derya Unutmaz, Min Lu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Recent advances in anti-infective drug discovery · 2025
    Article
  5. Article
  6. Frontiers in cellular and infection microbiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Bacterial pore-forming toxins.Microbiology (Reading, England) · 2022
    Article
  13. Review
  14. Identification of a domain critical forThe Journal of biological chemistry · 2020
    Article
  15. Toxins · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jie LiuPublic Health Research Institute, Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103.
Lina KozhayaJackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
Victor J TorresDepartment of Microbiology, New York University School of Medicine, New York, New York 10016.
Derya UnutmazJackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032.
Min LuPublic Health Research Institute, Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103. Electronic address: lum1@njms.rutgers.edu.
Jackson Laboratory · USRutgers, The State University of New Jersey · USNew York University · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
The Role of Scavenger Receptor gp340 in Mucosal HIV-1 Transmission and InhibitionR01AI094599 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI LU, MIN, MALAMUD, DANIEL · 2011 to 2016
$3.9M
NCI NIH HHS P30 CA034196NIAID NIH HHS R01 AI094599
6 · The paper itself

Abstract

The rapid emergence and dissemination of methicillin-resistant

Indexed as

Drug DiscoveryAmino Acid SequenceAnti-Bacterial AgentsBacterial ProteinsMethicillin-Resistant Staphylococcus aureusMolecular Docking SimulationProtein DomainsProtein MultimerizationProtein Structure, QuaternarySmall Molecule LibrariesVirulenceAnti-Bacterial AgentsBacterial ProteinsSmall Molecule Librariesalpha-toxinantivirulence therapydrug discoveryleukocidin ED (LukED)methicillin-resistant Staphylococcus aureus (MRSA)MRSAPanton-Valentine leukocidin (PVL)phosphatidylcholinepore-forming toxinstructural biologystructure-based drug designtoxinvirulence factor

Identifiers

PMID32179646
PMCPMC7196633
OpenAlexW3011371696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.