Evidence map›Paper›PMID 32179573›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2020

Antinociceptive and Immune Effects of Delta-9-Tetrahydrocannabinol or Cannabidiol in Male Versus Female Rats with Persistent Inflammatory Pain.

Stevie C Britch, Alan G Goodman, Jenny L Wiley, Abby M Pondelick, Rebecca M Craft

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Glucocorticoid-endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Natural Products Derived from Cannabis sativa for Pain Management.Handbook of experimental pharmacology · 2025
    Review
  14. Article
  15. FDA-approved cannabidiol [EpidiolexMilitary Medical Research · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stevie C BritchCenter on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky (S.C.B.); School of Molecular Biosciences, Paul G. Allen School for Global Animal Health (A.G.G.), Integrative Physiology and Neuroscience (A.M.P.), and Department of Psychology (R.M.C.), Washington State University, Pullman, Washington; and RTI International, Research Triangle Park, North Carolina (J.L.W.).
Alan G GoodmanCenter on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky (S.C.B.); School of Molecular Biosciences, Paul G. Allen School for Global Animal Health (A.G.G.), Integrative Physiology and Neuroscience (A.M.P.), and Department of Psychology (R.M.C.), Washington State University, Pullman, Washington; and RTI International, Research Triangle Park, North Carolina (J.L.W.).ORCID 0000-0001-6394-332X
Jenny L WileyCenter on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky (S.C.B.); School of Molecular Biosciences, Paul G. Allen School for Global Animal Health (A.G.G.), Integrative Physiology and Neuroscience (A.M.P.), and Department of Psychology (R.M.C.), Washington State University, Pullman, Washington; and RTI International, Research Triangle Park, North Carolina (J.L.W.).
Abby M PondelickCenter on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky (S.C.B.); School of Molecular Biosciences, Paul G. Allen School for Global Animal Health (A.G.G.), Integrative Physiology and Neuroscience (A.M.P.), and Department of Psychology (R.M.C.), Washington State University, Pullman, Washington; and RTI International, Research Triangle Park, North Carolina (J.L.W.).
Rebecca M CraftCenter on Drug and Alcohol Research, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky (S.C.B.); School of Molecular Biosciences, Paul G. Allen School for Global Animal Health (A.G.G.), Integrative Physiology and Neuroscience (A.M.P.), and Department of Psychology (R.M.C.), Washington State University, Pullman, Washington; and RTI International, Research Triangle Park, North Carolina (J.L.W.) Craft@wsu.edu.
University of Kentucky · US

Funding

Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Sex Differences in Cannabinoid Dependence and Analgesia (parent grant)R01DA016644 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 2004 to 2016
$3.9M
NIDA NIH HHS R01 DA016644NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

Chronic pain is the most common reason reported for using medical cannabis. The goal of this research was to determine whether the two primary phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are effective treatments for persistent inflammatory pain. In experiment 1, inflammation was induced by intraplantar injection of Complete Freund's adjuvant (CFA). Then THC (0.0-4.0 mg/kg, i.p.) or CBD (0.0-10 mg/kg, i.p.) was administered twice daily for 3 days. On day 4, THC, CBD, or vehicle was administered, and allodynia, hyperalgesia, weight-bearing, locomotor activity, and hindpaw edema were assessed 0.5-4 hours postinjection. In experiment 2, CFA or mineral oil (no-pain control)-treated rats were given THC (2.0 mg/kg, i.p.), CBD (10 mg/kg, i.p.), or vehicle in the same manner as in experiment 1. Four hours postinjection on day 4, serum samples were taken for analysis of cytokines known to influence inflammatory pain: interleukin (IL)-1

Indexed as

AnalgesicsAnimalsCannabidiolCannabinolChronic PainCytokinesDose-Response Relationship, DrugDrug ToleranceFemaleInflammationMaleRatsRats, Sprague-DawleySex CharacteristicsAnalgesicsCannabidiolCannabinolCytokines

Identifiers

PMID32179573
PMCPMC7250366
OpenAlexW3012466763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.